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CYTOMEGALOVIRUS PNEUMONITIS: THE ROLE OF TNF A AND B

CYTOMEGALOVIRUS PNEUMONITIS: THE ROLE OF TNF A AND B
巨细胞病毒肺炎:TNF A 和 B 的作用
批准号:
2217667
负责人:
John D Shanley
金额:
$23.26万
依托单位国家:
美国
项目类别:
财政年份:
1986
资助国家:
美国
项目状态:
已结题
起止时间:
1986-04-01 至 1994-11-30

项目摘要

项目成果

John D Shanley的其他基金

相关文献

中文摘要
翻译
描述:(改编自申请人摘要)严重的巨细胞病毒
英文摘要
DESCRIPTION: (Adapted from the applicant's abstract.) While serious CMV infections can involve a number of host tissues, the lungs are frequently involved in lethal CMV infections. In these experiments several murine models of CMV infection will be utilized in order to explore the cytokines, TNF-a and lymphotoxin (TNF-b), as mediators of tissue damage. The role of TNF-a and b in acute MCMV infection following sublethal and lethal virus challenge will be examined. Using a model of acute CMV infection, the amount of TNF expressed in tissue during lethal and sublethal virus challenge will be compared and the effect of exogenous TNF on acute CMV infection will be monitored. The effects of passive transfer of antibody to TNF on virus replication will be determined. To explore the role of TNF in lung injury, a murine model of pneumocystis associated MCMV and graft-versus-host disease will be used, comparing the levels of TNF during MCMV lung infection and pneumocystis. The production of TNF by lung cells during pneumocystis will be examined and it will be determined if production is antigen-specific or MHC-restricted. The effects of passive transfer of antibody to TNF and lymphotoxin on MCMV pneumocystis will also be determined. The Specific Aims of this project are: to determine the role of TNF-a and lymphotoxin in acute MCMV infection; and to determine the role of TNF-a and lymphotoxin in the pathogenesis of pneumocystis associated with combined MCMV infection and GVH disease.
期刊论文(9)
专著(0)
科研奖励(0)
会议论文
The folate antagonist, methotrexate, is a potent inhibitor of murine and human cytomegalovirus in vitro.
叶酸拮抗剂甲氨蝶呤在体外是小鼠和人类巨细胞病毒的有效抑制剂。
DOI: 10.1016/0166-3542(89)90012-0
发表时间: 1989
期刊: Antiviral research
影响因子: 7.6
作者: [Shanley,JD, Debs,RJ]
通讯作者: Debs,RJ
In vivo administration of monoclonal antibody to the NK 1.1 antigen of natural killer cells: effect on acute murine cytomegalovirus infection.
体内施用针对自然杀伤细胞 NK 1.1 抗原的单克隆抗体:对急性鼠巨细胞病毒感染的影响。
DOI: 10.1002/jmv.1890300113
发表时间: 1990
期刊: Journal of medical virology
影响因子: 12.7
作者: [Shanley,JD]
通讯作者: Shanley,JD
Modification of acute murine cytomegalovirus adrenal gland infection by adoptive spleen cell transfer.
通过过继脾细胞移植改变急性小鼠巨细胞病毒肾上腺感染。
DOI: 10.1128/jvi.61.1.23-28.1987
发表时间: 1987
期刊: Journal of virology
影响因子: 5.4
作者: [Shanley,JD]
通讯作者: Shanley,JD
Replication of human cytomegalovirus in cells deficient in beta 2-microglobulin gene expression.
人类巨细胞病毒在β2-微球蛋白基因表达缺陷的细胞中的复制。
DOI: 10.1099/0022-1317-75-10-2755
发表时间: 1994
期刊: The Journal of general virology
影响因子: --
作者: [Wu,QH, Trymbulak,W, Tatake,RJ, Forman,SJ, Zeff,RA, Shanley,JD]
通讯作者: Shanley,JD
7
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