GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS

肠系膜血管的神经节控制

• 批准号: 3339313
• 负责人: DAVID L KREULEN
• 金额: $ 7.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 1981
• 资助国家: 美国
• 起止时间: 1981-02-01 至 1987-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3339313
• 关键词: afferent nerve; autonomic reflex; electrophysiology; ganglions; gastrointestinal circulation; gastrointestinal motility /pressure; mechanoreceptors; mesentery; neuroanatomy; neuroeffector; neurons; neuropharmacology; vascular smooth muscle

The aim of this research is to delineate the role of nerve pathways involving the abdominal prevertebral ganglia in controlling mesenteric blood vessels and to determine the organization of the abdominal nerve-vessel system. Experiments have been designed to determine: (1) the organization of the sympathetic outflow to branches of the inferior mesenteric and celiac arteries and the inferior mesenteric and portal veins; (2) whether or not there are afferent pathways from the mesenteric vasculature to neurons in the prevertebral ganglia; (3) whether there are reflexes between different vascular regions in the mesentery and/or between the mesenteric vasculature and the musculature of the gastrointestinal tract; (4) the nature of neuroeffector transmission from the postganglionic fibers of the prevertebral ganglia to mesenteric vascular smooth muscle cells. These studies will involve anatomical, physiological and pharmacological approaches to these questions. In vitro preparations from guinea pigs, rabbits and cats that consist of the celiac plexus and inferior mesenteric ganglion attached to selected abdominal organs will be used. Preganglionic, postganglionic and afferent nerve fibers will be electrically stimulated. Electrophysiological techniques will be used to determine intracellular responses of neurons in the prevertebral ganglia and vascular smooth muscle cells. Pressure recording techniques will be used to distend and record the contractile responses of mesenteric vascular and gastrointestinal segments. Pharmacologic techniques will be used to determine the mechanisms which modulate neurotransmission in the ganglia and to the blood vessels to determine how these mechanisms can be altered with drug therapy. The goal of these studies will be to understand how the autonomic nervous system controls blood vessels and what role reflexes between the viscera plays in this control. This knowledge will help us to understand and design better treatment for diseases which involve the autonomic nervous system; the nerves themselves as well as the organs they innervate.

这项研究的目的是描绘神经通路的作用 涉及腹部椎前神经节控制肠系膜 血管并确定腹部的组织 神经血管系统。 实验的目的是确定：（1） 交感神经流向下肢分支的组织 肠系膜和腹腔动脉以及肠系膜下动脉和门脉 静脉； (2)有无来自肠系膜的传入通路 椎前神经节神经元的脉管系统； (3)是否有 肠系膜和/或肠系膜不同血管区域之间的反射 肠系膜脉管系统和胃肠道肌肉系统 道； (4) 节后神经效应器传递的性质 椎前神经节至肠系膜血管平滑肌的纤维 细胞。 这些研究将涉及解剖学、生理学和 这些问题的药理学方法。 体外制剂来自 豚鼠、兔子和猫由腹腔神经丛和 肠系膜下神经节附着在选定的腹部器官上 用过的。 节前、节后和传入神经纤维将 电刺激。 电生理学技术将用于 确定椎前神经节神经元的细胞内反应 和血管平滑肌细胞。 压力记录技术将 用于扩张和记录肠系膜血管的收缩反应 和胃肠道部分。 药理学技术将用于 确定调节神经节神经传递的机制 以及血管以确定如何改变这些机制 与药物治疗。 这些研究的目标是了解如何 自主神经系统控制血管及反射有何作用 脏腑之间的作用就在此控制之中。 这些知识将帮助我们 了解并设计更好的治疗方法来治疗涉及以下疾病的疾病 自主神经系统；神经本身以及它们所连接的器官 支配。