GANGLIONIC CONTROL OF MESENTERIC BLOOD VESSELS

这项研究的目的是描绘神经通路的作用。 累及腹椎前神经节控制肠系膜 血管和腹部组织的确定 神经血管系统。实验旨在确定：(1) 交感神经向下位分支流出的组织 肠系膜动脉和腹膜动脉以及肠系膜下动脉和门静脉 静脉；(2)是否有来自肠系膜的传入通路 椎前神经节内神经元的血管构筑； 肠系膜不同血管区域之间和/或肠系膜之间的反射 胃肠道的肠系膜血管系统和肌肉系统 (4)神经节后神经效应传递的性质。 椎前神经节至肠系膜血管平滑肌的纤维 细胞。这些研究将涉及解剖学、生理学和 解决这些问题的药理学方法。的体外制剂 豚鼠、兔子和猫，由腹腔神经丛和 附着于选定腹部器官的肠系膜下神经节将 使用。节前、节后和传入神经纤维 是电刺激的。电生理技术将被用来 测定椎前神经节神经元的细胞内反应 和血管平滑肌细胞。压力记录技术将是 用于扩张和记录肠系膜血管的收缩反应 和胃肠道节段。药理学技术将被用来 确定神经节内神经传递的调节机制 以及血管，以确定如何改变这些机制 用药物治疗。这些研究的目标将是了解 自主神经系统控制血管以及反射的作用 在这个控制中，内脏之间起作用。这一知识将帮助我们 了解和设计更好的疾病治疗方法，包括 自主神经系统；神经本身以及它们的器官 令人兴奋。

The aim of this research is to delineate the role of nerve pathways involving the abdominal prevertebral ganglia in controlling mesenteric blood vessels and to determine the organization of the abdominal nerve-vessel system. Experiments have been designed to determine: (1) the organization of the sympathetic outflow to branches of the inferior mesenteric and celiac arteries and the inferior mesenteric and portal veins; (2) whether or not there are afferent pathways from the mesenteric vasculature to neurons in the prevertebral ganglia; (3) whether there are reflexes between different vascular regions in the mesentery and/or between the mesenteric vasculature and the musculature of the gastrointestinal tract; (4) the nature of neuroeffector transmission from the postganglionic fibers of the prevertebral ganglia to mesenteric vascular smooth muscle cells. These studies will involve anatomical, physiological and pharmacological approaches to these questions. In vitro preparations from guinea pigs, rabbits and cats that consist of the celiac plexus and inferior mesenteric ganglion attached to selected abdominal organs will be used. Preganglionic, postganglionic and afferent nerve fibers will be electrically stimulated. Electrophysiological techniques will be used to determine intracellular responses of neurons in the prevertebral ganglia and vascular smooth muscle cells. Pressure recording techniques will be used to distend and record the contractile responses of mesenteric vascular and gastrointestinal segments. Pharmacologic techniques will be used to determine the mechanisms which modulate neurotransmission in the ganglia and to the blood vessels to determine how these mechanisms can be altered with drug therapy. The goal of these studies will be to understand how the autonomic nervous system controls blood vessels and what role reflexes between the viscera plays in this control. This knowledge will help us to understand and design better treatment for diseases which involve the autonomic nervous system; the nerves themselves as well as the organs they innervate.