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SPECIFICITY OF THE INNERVATION OF ARTERIES AND VEINS

动脉和静脉神经支配的特异性

基本信息

批准号：
6330135
负责人：
DAVID L KREULEN
金额：
$ 22.7万
依托单位：
MICHIGAN STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-12-20 至 2002-11-30
项目状态：
已结题

项目摘要

DESCRIPTION: (Adapted from the application) The control of the vascular system by the sympathetic nervous system depends on the organization of sympathetic neurons into function-specific pathways. The postganglionic sympathetic neuron plays a critical role in this organization. Characteristic morphological, neurochemical and electrophysiological features of these sympathetic neurons contribute to their specific functional pathways. Although it is known that sympathetic neurons in vascular pathways have distinct neurochemical characteristics, it is not known whether there are distinctions between neurons innervating arteries and veins. The functional separation between vascular resistance and capacitance is an important part of cardiovascular regulation. Four specific aims are proposed: 1. Test the uniqueness of the localization and transmitter phenotype of the neurons in prevertebral ganglia that innervate mesenteric arteries and veins. 2. Test the uniqueness of the electrophysiological characteristics of the neurons in prevertebral ganglia that innervate mesenteric arteries and veins. 3. Characterize the source and effects of selected sensory neurotransmitters in prevertebral ganglia that are related to the target organ (artery or vein). 4. Compare the release of ATP from sympathetic nerves innervating mesenteric arteries and veins. Achieving the objectives will define the nervous mechanisms underlying the separate control of resistance and capacitance vessels. The splanchnic circulation receives 30% of the cardiac output and contains about one-third of the total blood volume. In essential hypertension, vascular capacitance is initially reduced and this is followed by changes in resistance. The studies outlined in this proposal will enhance our understanding of the underlying mechanisms of this and related phenomena.

描述：（改编自应用程序）血管的控制交感神经系统依赖于交感神经系统的组织。交感神经元进入功能特异性通路。节后交感神经元在该组织中起关键作用。特征形态学、神经化学和电生理学这些交感神经元的特征有助于它们的特定功能。功能途径。虽然已知交感神经元在血管通路具有独特的神经化学特征，但事实并非如此目前还不清楚支配动脉的神经元和静脉。血管阻力和血管阻力之间的功能分离电容是心血管调节的重要部分。四具体目标是：1。测试本地化的唯一性，脊前神经节神经元的递质表型肠系膜动脉和静脉。 2. 测试椎前神经节神经元的电生理特性支配肠系膜动脉和静脉 3. 描述来源和椎前神经节中选定的感觉神经递质的作用与靶器官（动脉或静脉）相关。 4. 比较从支配肠系膜动脉的交感神经释放ATP，静脉实现目标将定义神经机制这是电阻和电容容器的单独控制的基础。的内脏循环接收30%的心输出量，占总血量的三分之一在原发性高血压中，电容最初减小，随后是阻力本建议中概述的研究将加强我们的了解这种现象和相关现象的潜在机制。