VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH

这项研究的目的是描述病毒的影响 生命早期呼吸系统疾病对出生后肺生长的影响 发展。副流感(仙台)病毒在大鼠体内的感染 作为人病毒性毛细支气管炎和肺炎的实验模型 婴儿。对婴儿病毒性呼吸道疾病的研究表明， 在生命的头两年，病毒感染通常与 持续异常的后续肺功能和更大的易感性 到慢性肺病。 拟议的研究将确定病理和形态计量学 幼年大鼠在肺部迅速受到感染时肺部发生的变化 不断增长。这项研究还将检查病毒学和免疫学 这些机制可能会使幼年动物更容易患上 早期生命中的病毒性肺损伤。定量形态研究将 关注出生后超微结构形态计量学的变化 肺泡实质的生长可能会降低弥散能力 在感染病毒的婴儿身上交换组织。呼吸道的形态计量学研究 病毒感染幼鼠的腐蚀铸型将集中在病毒诱导 可能导致传导障碍的呼吸道生长变化 航空公司。病毒引起的肺顺应性变化将通过以下方式进行评估 静态生理盐水压力-容量生理学研究。

The purpose of this research is to characterize the effects of viral respiratory disease during early life on postnatal lung growth and development. Parainfluenza (Sendai) virus infection in rats is being used as an experimental model of viral bronchiolitis and pneumonia in human infants. Studies on viral respiratory disease in infants have shown that viral infection in the first 2 years of life is often associated with persistently abnormal subsequent lung function and a greater predisposition to chronic lung disease. The proposed research will determine the pathologic and morphometric changes that occur in lungs of young rats infected when the lung is rapidly growing. The research will also examine virologic and immunologic mechanisms that may play a role in making young animals more susceptible to viral lung damage during early life. Quantitative morphology studies will focus in detail on ultrastructural morphometric alterations in postnatal growth of alveolar parenchyma that may decrease the diffusion capacity of exchange tissue in viral-infected infants. Morphometric studies on airway corrosion casts of viral-infected infant rats will focus on viral-induced changes in airway growth that may contribute to obstruction of conducting airways. Viral-induced changes in lung compliance will be assessed by static saline pressure-volume physiologic studies.