VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH

这项研究的目的是调查细胞和 细支气管性发育不全的组织机制 病毒性毛细支气管炎和肺炎引起的肺泡发育不良 早年的肺炎。感染副流感的大鼠 使用的动物模型为1型(仙台)病毒。形态测量学 和放射自显影的方法被用来调查 过程中细胞增殖和细胞数量的变化 出生后肺生长和病毒诱导的组织改变 损伤和炎症。此外，长期的影响， 病毒性毛细支气管炎对肺功能和呼吸道的影响 正在对大鼠的高反应性进行评估。近交系大鼠 对病毒性毛细支气管炎易感性不同的人将是 确定用于未来的研究，旨在研究遗传和 免疫机制在控制病毒感染中起重要作用 病毒性毛细支气管炎的病理后遗症进展 婴儿期。

The objective of this research is to investigate the cellular and tissue mechanisms responsible for bronchiolar hypoplasia and alveolar dysplasia that result from viral bronchiolitis and pneumonia during early life. Rats infected with parainfluenza type 1 (Sendai) virus are the animal model used. Morphometric and autoradiographic methods are being used to investigate changes in cell proliferation and cell numbers that occur during postnatal lung growth and that are altered by viral-induced tissue damage and inflammation. In addition, the long-term effects of viral bronchiolitis on pulmonary function and airway hyperreactivity in rats are being assessed. Inbred strains of rats that vary in their susceptibility to viral bronchiolitis will be identified for future studies aimed at investigating genetic and immunological mechanisms that are important in controlling the development of pathologic sequelae to viral bronchiolitis in infancy.