VIRAL INDUCED ALTERATIONS IN POSTNATAL PULMONARY GROWTH

这项研究的目的是描述病毒的影响， 呼吸道疾病对出生后肺部生长的影响， 发展 副流感（仙台）病毒感染大鼠正在使用 作为人类病毒性细支气管炎和肺炎的实验模型 婴儿。 对婴儿病毒性呼吸道疾病的研究表明， 在生命的头2年中的病毒感染通常与以下因素有关： 持续异常的后续肺功能和更大的倾向 慢性肺部疾病。 拟议的研究将确定病理和形态计量学 当肺部迅速感染时， 增长. 这项研究还将检查病毒学和免疫学 可能在使年轻动物更容易受到 病毒性肺损伤 定量形态学研究将 详细关注出生后的超微结构形态学改变， 肺泡实质的生长可能会降低 交换病毒感染婴儿的组织。 气道形态计量学研究 病毒感染的幼鼠的腐蚀模型将集中在病毒引起的 可能导致传导障碍的气道生长变化 航空公司. 将通过以下方法评估病毒诱导的肺顺应性变化 静态生理盐水压力-容量生理学研究。

The purpose of this research is to characterize the effects of viral respiratory disease during early life on postnatal lung growth and development. Parainfluenza (Sendai) virus infection in rats is being used as an experimental model of viral bronchiolitis and pneumonia in human infants. Studies on viral respiratory disease in infants have shown that viral infection in the first 2 years of life is often associated with persistently abnormal subsequent lung function and a greater predisposition to chronic lung disease. The proposed research will determine the pathologic and morphometric changes that occur in lungs of young rats infected when the lung is rapidly growing. The research will also examine virologic and immunologic mechanisms that may play a role in making young animals more susceptible to viral lung damage during early life. Quantitative morphology studies will focus in detail on ultrastructural morphometric alterations in postnatal growth of alveolar parenchyma that may decrease the diffusion capacity of exchange tissue in viral-infected infants. Morphometric studies on airway corrosion casts of viral-infected infant rats will focus on viral-induced changes in airway growth that may contribute to obstruction of conducting airways. Viral-induced changes in lung compliance will be assessed by static saline pressure-volume physiologic studies.