POLYUNSATURATES AND KC1 TO CONTROL MILD HYPERTENSION

3项轻度抑郁症患者的随机安慰剂对照临床试验 建议使用高血压患者来评估 鱼油和膳食中的多不饱和脂肪酸 镁，单独和补充钾。 1. 鱼油中的n-3（omega-3）脂肪酸有利地影响 血管舒张和血管收缩前列腺素类之间的平衡，以及 在正常人中发现了鱼油的消肿作用。 志愿者 因此，两剂高纯度和 标准化的n-3脂肪酸制剂，4g和8g/d， 对30名高血压患者进行了为期三个月的治疗， 在交叉设计中的第三个三个月期间给予安慰剂。 2. 镁主要是一种细胞内阳离子， 平滑肌在动物模型中，部分是通过减少 血管收缩剂钙的细胞内浓度。 那里 提示性证据表明，在人类中， (BP)通过补充镁来降低。 此外，由于饮食 镁调节细胞钾含量，可能存在协同作用 这两种阳离子之间的联系。 因此，120 未经治疗的轻度高血压患者将被随机分为四组 30例受试者将接受每日1） 镁，375毫克，2）钾60毫摩尔，3）镁和 钾，或4）匹配的安慰剂。 研究古希腊 镁的机制，细胞内镁和游离镁的变化 将测定受试者血液单核细胞中的钙 与血压的变化有关。 3. 将对镁和钾进行类似的试验 在轻度高血压患者中， 利尿剂消耗镁和钾， 可以增强饱腹感。 血压将在整个过程中多次测量 在诊所和受试者家中进行研究， 广泛的治疗效果记录。 每项研究将有超过 90%的把握度可检测到治疗的显著疗效 与安慰剂相比，收缩压为4mm，舒张压为3mm。 生化 将获得对每种治疗的依从性的验证。 发现一种有效的膳食补充剂来治疗轻度 高血压将具有极大的兴趣和实际重要性。

Three randomized placebo-controlled clinical trials in mild hypertensives are proposed to assess the hypotensive potential of dietary polyunsaturated fatty acids in fish, oil, and of dietary magnesium, alone and with supplemental potassium. 1. The n-3 (omega-3) fatty acids in fish oil favorably affect the balance between vasodilating and vasoconstricting prostanoids, and hypotensive effects of fish oils have been found in normal volunteers. Therefore, two doses of a highly purified and standardized preparation of n-3 fatty acids, 4g and 8g/d, will be administered to 30 hypertensive patients for three months, and placebo for a third three-month period in a crossover design. 2. Magnesium is primarily an intracellular cation that relaxes smooth muscle in animal models, in part by decreasing the intracellular concentration of the vasoconstrictor, calcium. There is suggestive evidence that, in humans, systemic blood pressure (BP) is lowered by supplemental magnesium. Moreover, since dietary magnesium regulates cellular potassium content, synergism may exist between these two cations for lowering BP. Therefore, 120 untreated mild hypertensives will be randomized into four groups of 30 subjects who will receive daily for six months either 1) magnesium, 375mg, 2) potassium 60mmoles, 3) magnesium and potassium, or 4) matching placebos. To study the hypotensive mechanism of magnesium, changes in intracellular magnesium and free calcium will be determined in the subjects' blood mononuclear cells and related to the changes in BP. 3. A similar trial of magnesium and potassium will be conducted in mild hypertensives who are being treated with diuretics since diuretics deplete Mg and K and the hypotensive effect of oral repletion may be potentiated. Blood pressure will be measured on multiple occasions throughout the study at the clinic and at the subjects' homes to provide an extensive record of treatment effects. Each study will have over 90% power to detect a significant hypotensive effect of treatment over placebo of 4mm systolic and 3mm diastolic BP. Biochemical validation of compliance with each treatment will be obtained. The discovery of an effective dietary supplement to treat mild hypertension would be of great interest and practical importance.