MYOCARDIAL IMAGING IN ISCHEMIA AND INFARCTION

缺血和梗死的心肌成像

• 批准号: 3344528
• 负责人: GERALD Michael POHOST
• 金额: $ 34.5万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-12-01 至 1986-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3344528
• 关键词: diagnosis quality /standard; heart imaging /visualization /scanning; myocardial infarction; myocardial ischemia /hypoxia

This renewal application builds upon the two new radio-nuclide imaging approaches which have been funded for the past 15 months in NHBI Grant HL-21751. These approaches are serial imaging after a single dose of 201T1 to distinguish between normal, viable ischemic, and infarcted myocardium and gamma imaging of radiolabeled specific antibody to cardiac myosin to identify regions of acute myocardial infarction. We have now compiled substantial evidence that redistribution of 201T1 into initial defects on serial imaging studies is primarily related to myocardial viability. Accordingly, in the present protocol we will explore methods to objectively assess the serial imaging sequence in order to determine the ischemic state, its severity and its reversibility. Regional rate of myocardial 201T1 transport and the concentration of pulmonary 201T1 relative to myocardium will be derived and determined. In addition, radiolabeled antimyosin antibody will be prepared and applied clinically. In addition to a standard gamma camera imaging, a positron emitting radiolabel, 68 Ga will be employed to allow transverse section imaging after intracoronary administration of radiolabeled antimyosin. A new dimension has been added to the evaluation of acutely ischemic or infarcted myocardium by studying the localization of 18F-, a positron emitting radionuclide and the redistribution of endogenous 19F as determined by nuclear magnetic resonance (nmr) spectroscopy. 18F- is a bone seeking agent which accumulates in acutely infarcted myocardium and allows transverse emission tomography. We will evaluate its sensitivity, its specificity and its utility in quantification of infarct size. We have also found that an easily defineable reservoir of endogenous myocardial 19F exists and is easily detected with nmr. Preliminary studies suggest that endogenous 19F is depleted from ischemic myocardial zones. We propose to further evaluate 19F redistribution and determine if a 19F leak might be detected in the peripheral blood. By elucidating the mechanisms of thallium uptake and clearance, and correlating these with fluoride uptake and antimyosin deposition, the sensitivity, specificity and clinical application of imaging the ischemic myocardium will be enhanced.

这个更新的应用程序建立在两个新的放射性核素成像

项目成果

Assessment of regional myocardial perfusion with thallium imaging during transient left anterior descending coronary arterial occlusion during angioplasty.

血管成形术期间短暂左前降支冠状动脉闭塞期间用铊成像评估局部心肌灌注。

• DOI: 10.1016/0002-9149(86)90678-8
• 发表时间: 1986
• 期刊: The American journal of cardiology
• 作者: Wiske,PS;Palacios,I;Block,PC;O'Gara,P;Strauss,HW;Okada,RD;Boucher,CA
• 通讯作者: Boucher,CA

Correlates of lung/heart ratio of thallium-201 in coronary artery disease.

冠状动脉疾病中铊 201 的肺/心脏比率的相关性。

• 发表时间: 1987
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Homma,S;Kaul,S;Boucher,CA
• 通讯作者: Boucher,CA

The importance of defining left ventricular area at risk in vivo during acute myocardial infarction: an experimental evaluation with myocardial contrast two-dimensional echocardiography.

• DOI: 10.1161/01.cir.75.6.1249
• 发表时间: 1987-06
• 期刊: Circulation
• 影响因子: 37.8
• 作者: Sanjiv Kaul;W. Glasheen;T. D. Ruddy;N. Pandian;A. Weyman;Robert D. Okada

Usefulness of oral dipyridamole suspension for stress thallium imaging without exercise in the detection of coronary artery disease.

口服双嘧达莫混悬液在不运动的情况下进行应激铊成像在检测冠状动脉疾病中的作用。

• DOI: 10.1016/0002-9149(86)90824-6
• 发表时间: 1986
• 期刊: The American journal of cardiology
• 作者: Homma,S;Callahan,RJ;Ameer,B;McKusick,KA;Strauss,HW;Okada,RD;Boucher,CA
• 通讯作者: Boucher,CA

Determination of the quantitative thallium imaging variables that optimize detection of coronary artery disease.

确定优化冠状动脉疾病检测的定量铊成像变量。

• DOI: 10.1016/s0735-1097(86)80462-4
• 发表时间: 1986
• 期刊: Journal of the American College of Cardiology
• 影响因子: 24
• 作者: Kaul,S;Boucher,CA;Newell,JB;Chesler,DA;Greenberg,JM;Okada,RD;Strauss,HW;Dinsmore,RE;Pohost,GM
• 通讯作者: Pohost,GM