TRIGEMINAL MODULATION OF AUTONOMIC BEHAVIOR

自主行为的三叉神经调节

• 批准号: 3354776
• 负责人: W MICHAEL PANNETON
• 金额: $ 17.64万
• 依托单位: SAINT LOUIS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-04-01 至 1996-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3354776
• 关键词: Rodentias; autonomic reflex; brain stem; cardiovascular function; efferent nerve; electrostimulus; laryngeal nerves; nasopharynx; neural inhibition; neuroanatomy; neuropharmacology; pons; respiratory function; sensorimotor system; solitary tract nucleus; sudden infant death syndrome; trigeminal nerve

The long term goal of this application is to establish the brainstem circuits through which trigeminal neurons modulate cardiorespiratory activity in mammals. The cardiorespiratory depression (the diving response) seen after stimulation of the upper respiratory tract in the muskrat serves as the model. The aims for this proposal specifically are to 1) demonstrate the role of the nucleus tractus solitarii in the cardiorespiratory depression after URT stimulation; 2) define the efferent projections of the peribrachial region in the muskrat; and, 3) locate cardiomotor neurons in the muskrat. The nasal part of the upper respiratory tract will be stimulated with ammonia vapors, or electrically, while lower parts of the upper respiratory tract will be stimulated with electrical excitation of the superior laryngeal nerve. Experiments in aim 1 documenting the change in the respiratory and cardiovascular responses to URT stimulation after lesions of the dorsomedial medulla will determine if the nucleus tractus solitarii is important in the diving response. No change in the responses would suggest the circuits for the diving response is mediated by other routes. In aims 2 and 3, neuroanatomical methods employing both the anterograde and retrograde transport of tracer substances will determine parabrachial efferent projections, especially those to the ventrolateral medulla, and the location of motor neurons to the heart. Data from these experiments will provide the anatomical substrate tp guide future physiological investigations. Stimulation of the upper respiratory tract in man causes respiratory and cardiovascular depression. Such depression is especially pronounced in infants and could lead to their death. The Sudden Infant Death Syndrome, the etiology which is unknown, is the leading cause of mortality in the neonate. Understanding the brainstem mechanisms governing cardiorespiratory depression after stimulation of the upper respiratory tract may provide a neurological explanation for this syndrome.

该应用程序的长期目标是建立脑干 三叉神经元调节心肺的电路 哺乳动物的活性。 心肺抑郁症（潜水 反应）在刺激上呼吸道后看到 马斯克拉特用作模型。 该提议的目的是 至1）演示核曲纳氏核的作用 URT刺激后心肺抑郁症； 2）定义出现 穆斯克拉特的周围区域的投影； 3）定位 麝香鼠中的心脏病神经元。 上呼吸道的鼻部将被刺激 氨蒸气或电蒸气，而上呼吸道下部 将刺激上级的电激发刺激。 喉神经。 AIM 1中的实验记录了变化 病变后对URT刺激的呼吸和心血管反应 背部髓质的髓质是否会确定soliratirii nucleus tractus solitarii 在潜水反应中很重要。 回答不会改变 建议潜水响应的电路由其他路线介导。 在AIM 2和3中，采用顺行和同时采用的神经解剖学方法 示踪剂物质的逆行运输将确定副阶层 传出的预测，尤其是对腹外侧髓质的预测， 运动神经元心脏的位置。 这些实验的数据 将提供解剖基板TP指南未来的生理 调查。 人类刺激上呼吸道引起呼吸和 心血管抑郁症。 这种抑郁症特别明显 婴儿，可能导致他们的死亡。 突然的婴儿死亡综合症， 未知的病因是死亡率的主要原因 新生儿。 了解管理的脑干机制 刺激上呼吸道后心肺抑郁症 区域可以为该综合征提供神经系统解释。