MASS ACTION OF HUMAN NEOCORTEX

人类新皮质的大规模行动

• 批准号: 3382763
• 负责人: ALAN S GEVINS
• 金额: $ 43.4万
• 依托单位: EEG SYSTEMS LABORATORY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1996-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3382763
• 关键词: cerebral cortex; communication disorders; computer simulation; electroencephalography; evoked potentials; generalized seizures; human subject; magnetic resonance imaging; mathematical model; mental process; model design /development; neocortex; neural information processing; perception; psychophysiology; sensorimotor system; sensory discrimination; stimulus /response; stimulus interval

The long-term objective of this project is to develop a theory of brain function that explains the dynamics of the cerebral cortex in the operations of sensation, perception, conception, memory and other cognitive processes. The long-term result is expected to be a set of procedures, based on a new understanding of the fundamental physical "code" underlying mental process, that would allow precise clinical evaluation of malfunctions of the brain's "information processing" in disorders such as schizophrenia. The specific aims of this project are: (1) to advance understanding of neurocognitive processes by providing more detailed and specific measurements of the spatial and temporal characteristics of neuroelectric neurocognitive signals; and (2) to test and extend theories and analytic methods of mass neural action developed in mammalian paleocortex to the human neocortex. This ill involve measuring detailed spatial patterns of low and high frequency neuroelectric activity related to stimulus, response and cognitive factors of a somatosensory-motor judgment task, including the tie intervals during which these patterns occur, the size and location of their spatial domains, and temporal spectral bands in which the activity is concentrated. We plan to do this first with recordings from subdural electrode grids implanted for diagnostic purposes in patients wit refractory seizures. Then we will extend the analysis to arrays of scalp electrodes, first from the same patients and then from healthy subjects. Substantive progress during the first 2 years of this grant includes: development of a task and methods to record and analyze EEGs from 124- electrode scalp arrays and 60-channel subdural electrode grids; completion of nine 124-channel calibration recordings during finger stimulation and 3 60-channel subdural grid recordings from patients performing the somatosensory discrimination task; development of unique algorithms and software for 3-dimensional compute reconstruction sand modeling of subjects' brains from Magnetic Resonance Images (MRIs); and extensive efforts to disseminate information about our methods and results to other researchers. Preliminary analysis of the subdural data suggests that analytic techniques originally developed for paleocortex will be applicable to the human neocortex. Preliminary analysis of the scalp EEG data and 3-D MRI brain models suggest that great improvements in functional localization from scalp-recorded data are forthcoming. In summary, the various components of the research program are all well underway, and we propose to continue with data collection, algorithm development, signal processing and data analysis. We expect the this project will result in substantial advances in measuring and understanding the mass neural substrate of human cognition.

这个项目的长期目标是发展一种大脑理论 解释大脑皮质动态变化的功能 感觉、知觉、概念、记忆和其他认知的操作 流程。预计长期结果将是一套程序， 基于对潜在的基本物理“代码”的新理解 心理过程，这将允许精确的临床评估 大脑“信息处理”功能障碍 精神分裂症。本项目的具体目标是：(1)推进 通过提供更详细和更详细的 空间和时间特征的具体测量 神经电神经认知信号；(2)检验和扩展理论 以及在哺乳动物中发展的大量神经动作的分析方法 古大脑皮层到人类新大脑皮层。这将涉及到测量详细的 与低频和高频神经电活动相关的空间模式 对体感运动的刺激、反应和认知因素的影响 判断任务，包括这些模式之间的平局间隔 发生，其空间域的大小和位置，以及时间 活动集中的光谱带。我们计划这样做 首先通过植入硬膜下电极网的记录 难治性癫痫患者的诊断目的。那我们就会 将分析扩展到头皮电极阵列，首先从相同的 然后从健康受试者身上提取。 这笔赠款头两年的实质性进展包括： 开发记录和分析124例脑电的任务和方法 电极头皮阵列和60通道硬膜下电极网.完工 在手指刺激期间的9个124通道校准记录和3个 60导联硬脑膜下格栅记录 体感辨别任务；开发独特的算法和 三维计算机重建砂体造型软件 受试者大脑的核磁共振成像(MRI)；和广泛的 努力将有关我们的方法和结果的信息传播给其他人 研究人员。对硬膜下数据的初步分析表明 最初为古大脑皮层开发的分析技术将适用 人类的新大脑皮层。头皮脑电数据与三维图像的初步分析 核磁共振脑模型表明，在功能定位方面有很大的改善 从头皮记录的数据即将到来。 总而言之，研究计划的各个组成部分都很好 正在进行中，我们建议继续收集数据，算法 开发、信号处理和数据分析。我们预计这将是 该项目将在测量和理解方面取得实质性进展 人类认知的大量神经底物。