CLASSIFICATION OF EARLY-ONSET DYSTHYMIA

早发性心境恶劣的分类

• 批准号: 3385604
• 负责人: Daniel N Klein
• 金额: $ 22.07万
• 依托单位: STATE UNIVERSITY NEW YORK STONY BROOK
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-04-01 至 1995-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3385604
• 关键词: clinical depression; disease /disorder classification; family; genetic disorder diagnosis; human subject; major depression; medical records; mental disorder diagnosis; mood disorders; personality disorders

The relationship between characterological depression, or DSM-III-R primary early-onset dysthymia (PEOD), and the major affective and personality disorders has long been debated. The PI's preliminary work suggests that PEOD is a complex condition with links to both the major mood and personality disorders. The present proposal seeks to extend this work with a clinical and family study of PEOD. Subjects will include 100 outpatients with PEOD, 50 outpatients with episodic major depression (EMD), and 50 normal controls, and their first-degree relatives. Four major questions will be addressed: a. Is PEOD a more severe form of mood disorder than EMD from the standpoint of familial transmission? b. Which personality disorders are more common in PEOD than EMD? c. Other than mood disorders, are there other familial factors which distinguish PEOD from EMD? d. Which of five models of the relationships between PEOD and the major affective and Axis II disorders best explains the pattern of mood and personality disorders in relatives of PEOD, EMD, and normal probands?

性格抑郁与DSM-III-R原发病的关系 早发性恶劣心境障碍(PEOD)及其主要情感因素和人格特征 关于精神障碍的争论由来已久。私家侦探的初步工作表明 PEOD是一种复杂的疾病，与主要情绪和 人格障碍。本提案力求将这项工作扩展到 PEOD的临床和家系研究研究对象将包括100名门诊患者 使用PEOD，50名发作性重度抑郁症(EMD)门诊患者，以及50名 正常对照和他们的一级亲属。四大问题 将解决以下问题： A.PEOD是一种比EMD更严重的情绪障碍吗 关于家族遗传的观点？ 哪些人格障碍在PEOD患者中比在EMD患者中更常见？ 除了情绪障碍，还有其他的家庭因素吗？ 区分PEOD和EMD？ D.以下五种模式中的哪一种 严重的情感障碍和轴II障碍最能解释情绪模式 与PEOD、EMD和正常亲属的人格障碍 前辈？