Towards excited state dynamics in nucleosides

核苷激发态动力学

• 批准号: EP/J007145/1
• 负责人: Vasilios Stavros
• 金额: $ 39.97万
• 依托单位: University of Warwick
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2012
• 资助国家: 英国
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FJ007145%2F1
• 关键词: Towards; excited; state; dynamics; nucleosides

The objective of this proposal is to study ultrafast UV-laser-induced dynamics in the DNA bases adenine and guanine as a stepping stone towards the nucleosides adenosine and guanosine. Funding will enable the PI to implement laser desorption into his laboratory so that these nucleosides can be brought into vacuum without decomposition and hence their ultrafast photochemistry studied in the gas-phase for the first time. Complementary high level calculations will provide critical guidance to interpreting the experimental results whilst posing new challenges to theoreticians as these studies will explore the complex interplay between multiple reaction paths and the ways these paths are coupled with one another with increasing molecular complexity. The PI, CoI and RCoI are ideally placed to undertake this exciting and ambitious research, which will begin to bridge the gap between the photochemistry of the DNA bases and that of nucleosides, and ultimately help elucidate the 'molecular mechanisms of the photostability of life'.

本提案的目的是研究超快紫外激光诱导的DNA碱基腺嘌呤和鸟嘌呤的动力学作为迈向核苷腺苷和鸟苷的垫脚石。资金将使PI能够在他的实验室中实施激光解吸，以便这些核苷可以在不分解的情况下进入真空，从而首次在气相中研究它们的超快光化学。补充的高水平计算将为解释实验结果提供关键指导，同时对理论家提出新的挑战，因为这些研究将探索多个反应路径之间的复杂相互作用以及这些路径随着分子复杂性的增加而相互耦合的方式。PI、CoI和RCoI是进行这项激动人心的雄心勃勃的研究的理想选择，该研究将开始弥合DNA碱基和核苷的光化学之间的差距，并最终帮助阐明“生命光稳定性的分子机制”。

项目成果

Time-resolved photoelectron imaging of the isolated deprotonated nucleotides

• DOI: 10.1039/c4sc01493f
• 发表时间: 2014-01-01
• 期刊: CHEMICAL SCIENCE
• 影响因子: 8.4
• 作者: Chatterley, Adam S.;West, Christopher W.;Verlet, Jan R. R.
• 通讯作者: Verlet, Jan R. R.

Retaining individualities: the photodynamics of self-ordering porphyrin assemblies.

• DOI: 10.1039/c5cc09095d
• 发表时间: 2016-01-31
• 期刊: Chemical communications (Cambridge, England)
• 作者: Quan WD;Pitto-Barry A;Baker LA;Stulz E;Napier R;O'Reilly RK;Stavros VG
• 通讯作者: Stavros VG