PATHOGENIC ROLE FOR A SERUM FACTOR IN REYE'S SYNDROME

雷伊氏综合征的特征是严重的线粒体损伤，由 危重期儿童肝活检的电子显微镜观察 疾病的威胁。这个项目的目标是研究可能的原因 线粒体受损。这项研究是基于一种物质的假设 血清中可能检测到对线粒体有害的物质。雷伊氏患者血清 因此将在几种线粒体功能的体外测试中进行测试， 包括：瓜氨酸合成、氧化磷酸化、脂肪酸 氧化和蛋白质合成。如果雷伊的血清有不同于 对于正常血清，活性物质将被分离并鉴定为 确定这种疾病可能的致病作用。此外，还研究了 如何调节正常的线粒体功能将继续下去，以便 提高预测不同行业的共同点的可能性 雷伊氏综合征的特征代谢异常。

Reye's Syndrome is characterized by severe mitochondrial injury as determined by electron microscpoy of liver biopsies obtained from children in critical stages of illness. The goal of this project is to study possible causes of the mitochondrial damage. The study is based on the hypothesis that a substance deleterious to mitochondria might be detected in serum. Reye's patient serum will therefore be tested in several in vitro assays of mitochondrial function, including: citrulline synthesis, oxidative phosphorylation, fatty acid oxidation, and protein synthesis. If Reye's serum has effects different from those of normal serum, the active substance will be isolated and identified to determine a possible pathogenic role in this illness. In addition, the study of how normal mitochondrial function is regulated will continue in order to increase the potential for predicting the common denominator for the diverse metabolic abnormalities that characterize Reye's syndrome.