MASS ACTION OF HUMAN NEOCORTEX

人类新皮质的大规模行动

• 批准号: 3382761
• 负责人: ALAN S GEVINS
• 金额: $ 32.65万
• 依托单位: EEG SYSTEMS LABORATORY
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-03-01 至 1991-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3382761
• 关键词: cerebral cortex; communication disorders; electroencephalography; evoked potentials; mental process; perception; psychophysiology; sensorimotor system; sensory discrimination; stimulus /response; stimulus interval

The long-term objective is to develop a theory of brain function that explains the dynamics of cerebral cortex in the operations of sensation, perception, decision, and response. The long-term result is expected to be a set of procedures, based on a new understanding of the fundamental physical "code" underlying mental processes, that would allow precise clinical evaluation of malfunctions of the cerebral cortex in information processing disorders such as schizophrenia. The immediate aim is to extend theories and analytic methods of mass neural action developed in mammalian paleocortex to scalp-recorded human event-related potentials (ERPs). State-of-the-art recording and analysis methods will facilitate the attempt to uncover basic patterns of mass neural activity that carry task-specific information processed by the human cerebral cortex. Neuroelectric data will be recorded from an array of 128 electrodes placed on the scalp of human volunteers making split-second discriminations of somatic stimuli. The analysis will focus on a search for the borad-band, high-frequency, spatiotemporal "carrier wave" hypothesized by theory, and found in animal studies, to be the manifestation of task-related mass neural processing. Extensive preprocessing will filter out contaminants, and reduce volume conduction distortion of the potentials. Single-trial spatial amplitude patterns, constructed for a range of temporal bandpass filters with differing center frequency and bandwidth, will be optimized based on their ability to correctly discriminate the three somatic stimulus classes presented in this task, and the three response types elicited by the stimuli. It is expected that the hypothesized "carrier wave" will be mapped and described, that the underlying cortical neural activity patterns will be deduced, and that theories describing the generation of these neural activity patterns will be enabled.

长期目标是发展一种大脑功能理论 这解释了大脑皮层的动力学， 感觉、知觉、决定和反应。 长期 预计结果将是一套程序，根据新的 理解基本的物理“代码” 心理过程，这将允许精确的临床评估， 大脑皮层信息处理功能障碍 精神分裂症等疾病。 当前的目标是扩大 群体神经活动的理论和分析方法， 哺乳动物的古皮层与人类头皮记录的事件相关 电位（ERP）。 最先进的记录和分析 方法将有助于试图揭示的基本模式， 携带特定任务信息的大量神经活动 由人类大脑皮层处理。 神经电数据将 从头皮上放置的128个电极阵列中记录 人类志愿者在瞬间区分 躯体刺激 分析的重点是寻找 宽带高频时空“载波” 理论上假设，并在动物研究中发现， 与任务相关的群体神经处理的表现。 广泛 预处理将过滤掉污染物， 电位的传导畸变。 单次试验空间 振幅模式，为时间带通范围构建 具有不同中心频率和带宽的滤波器， 根据他们正确区分 在这项任务中提出了三个躯体刺激类， 三种由刺激引起的反应类型。 预计在 将映射和描述假设的“载波”， 大脑皮层的神经活动模式 推论，而描述这些产生的理论 将启用神经活动模式。