ARACHNOIDITIS AND ROOT SHEATH AMPUTATION

蛛网膜炎和根鞘截肢术

• 批准号: 3395460
• 负责人: VICTOR M HAUGHTON
• 金额: $ 18.07万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-04-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3395460
• 关键词: central nervous system disorders; diagnosis procedure safety; disease /disorder model; fluorescence microscopy; genetic manipulation; histology; iatrogenic disease; inflammation; meningitis; microscopy; neurosurgery; pathologic process; postoperative complications

In clinical studies arachnoiditis has been attributed most commonly to myelographic contrast media, or spinal surgery. Experimental studies have verified that aqueous or oily myelographic contrast media may produce arachnoiditis. In some cases of arachnoiditis, especially focal root sheath scarring, the cause has not been clarified. We propose to examine the role of two potential contributing factors to the devolpment of focal arachnoiditis: anatomic distortion and compression of a nerve root sheath and local exposure of a nerve root sheath to some components of nucleus pulposus. Nerve rot compression will be produced by operative placement of small bone fragements in an appropriate location to stretch the nerve root. Exposure to components of intervertebral disc material will be produced by injection of washed polytroned monkey nucleus pulposus or specific components of interevertebral disc into the epidural space surrounding a nerve root. These animals will be studied at 12 weeks with myelography to determine the extent of arachnoiditis. They will then be sacrificed and the lumbar arachnoid examined and scored by light microscopy using previously published criteria for arachnoiditis. Following studies in previously normal animals, the effect of spinal surgery and contrast myelography on the arachnoiditis caused by nerve compression or exposure to disc material will be examined.

在临床研究中，蛛网膜炎最常见的原因是 脊髓造影剂，或脊柱手术。实验研究已经 已验证水性或油性脊髓造影剂可能会产生 蛛网膜炎。在某些蛛网膜炎病例中，尤其是局灶性神经根 鞘疤痕形成，原因尚不清楚。我们建议研究 两种潜在因素在震源发展中的作用 蛛网膜炎：神经根鞘的解剖扭曲和压迫 神经根鞘局部暴露于核的某些成分 牙髓。神经腐烂压迫将通过手术放置 在适当的位置有小的骨碎片来伸展神经 根部。接触到椎间盘材料的成分将是 通过注射洗净的多道猴子髓核或 将特定成分的椎间盘入硬膜外间隙 围绕着神经根。这些动物将在12周时进行研究 脊髓造影术以确定蛛网膜炎的程度。到那时，他们将成为 处死动物，光镜检查腰椎蛛网膜区评分 使用先前公布的蛛网膜炎标准。以下研究 在以前的正常动物中，脊柱手术和造影剂的效果 脊髓造影术对神经受压或暴露于神经的蛛网膜炎的诊断 将对光盘材料进行检查。