ARACHNOIDITIS AND ROOT SHEATH AMPUTATION

蛛网膜炎和根鞘截肢术

• 批准号: 3395458
• 负责人: VICTOR M HAUGHTON
• 金额: $ 17.86万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 1978
• 资助国家: 美国
• 起止时间: 1978-04-01 至 1989-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3395458
• 关键词: central nervous system disorders; diagnosis procedure safety; disease /disorder model; fluorescence microscopy; genetic manipulation; histology; iatrogenic disease; inflammation; meningitis; microscopy; neurosurgery; pathologic process; postoperative complications

In clinical studies arachnoiditis has been attributed most commonly to myelographic contrast media, or spinal surgery. Experimental studies have verified that aqueous or oily myelographic contrast media may produce arachnoiditis. In some cases of arachnoiditis, especially focal root sheath scarring, the cause has not been clarified. We propose to examine the role of two potential contributing factors to the devolpment of focal arachnoiditis: anatomic distortion and compression of a nerve root sheath and local exposure of a nerve root sheath to some components of nucleus pulposus. Nerve rot compression will be produced by operative placement of small bone fragements in an appropriate location to stretch the nerve root. Exposure to components of intervertebral disc material will be produced by injection of washed polytroned monkey nucleus pulposus or specific components of interevertebral disc into the epidural space surrounding a nerve root. These animals will be studied at 12 weeks with myelography to determine the extent of arachnoiditis. They will then be sacrificed and the lumbar arachnoid examined and scored by light microscopy using previously published criteria for arachnoiditis. Following studies in previously normal animals, the effect of spinal surgery and contrast myelography on the arachnoiditis caused by nerve compression or exposure to disc material will be examined.

在临床研究中，蛛网膜炎最常见的原因是 脊髓造影剂或脊柱手术。 实验研究 证实水性或油性脊髓造影剂可能产生 蛛网膜炎。 在某些情况下，蛛网膜炎，特别是局灶性根 鞘管瘢痕，原因尚未阐明。 我们建议研究 两个潜在促成因素对焦点发展的作用 蛛网膜炎：神经根鞘的解剖扭曲和压迫 以及神经根鞘局部暴露于核的某些成分 髓。 神经腐烂压迫将通过手术放置 在适当位置的小骨碎片拉伸神经 root. 暴露于椎间盘材料的成分将是 通过注射清洗过的多核猴髓核或 椎间盘的特定成分进入硬膜外腔 包围着神经根 这些动物将在12周时进行研究， 脊髓造影以确定蛛网膜炎的程度。 于其后向业主悉数 处死动物，通过光学显微镜检查腰椎蛛网膜并评分 使用先前发表的蛛网膜炎标准。 以下研究 在以前正常的动物中，脊柱手术和对比剂的作用 脊髓造影对蛛网膜炎引起的神经压迫或暴露 将检查圆盘材料。