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ARACHNOIDITIS AND ROOT SHEATH AMPUTATION

蛛网膜炎和根鞘截肢术

基本信息

批准号：
3395461
负责人：
VICTOR M HAUGHTON
金额：
$ 17.44万
依托单位：
MEDICAL COLLEGE OF WISCONSIN
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
起止时间：
1978-04-01 至 1990-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3395461
关键词：
Macaca central nervous system disorders diagnosis procedure safety disease /disorder model fluorescence microscopy genetic manipulation histology iatrogenic disease inflammation meningitis microscopy neurosurgery pathologic process postoperative complications

项目摘要

In clinical studies arachnoiditis has been attributed most commonly to myelographic contrast media, or spinal surgery. Experimental studies have verified that aqueous or oily myelographic contrast media may produce arachnoiditis. In some cases of arachnoiditis, especially focal root sheath scarring, the cause has not been clarified. We propose to examine the role of two potential contributing factors to the devolpment of focal arachnoiditis: anatomic distortion and compression of a nerve root sheath and local exposure of a nerve root sheath to some components of nucleus pulposus. Nerve rot compression will be produced by operative placement of small bone fragements in an appropriate location to stretch the nerve root. Exposure to components of intervertebral disc material will be produced by injection of washed polytroned monkey nucleus pulposus or specific components of interevertebral disc into the epidural space surrounding a nerve root. These animals will be studied at 12 weeks with myelography to determine the extent of arachnoiditis. They will then be sacrificed and the lumbar arachnoid examined and scored by light microscopy using previously published criteria for arachnoiditis. Following studies in previously normal animals, the effect of spinal surgery and contrast myelography on the arachnoiditis caused by nerve compression or exposure to disc material will be examined.

在临床研究中，蛛网膜炎最常见的原因是脊髓造影剂，或脊柱手术。实验研究已经已验证水性或油性脊髓造影剂可能会产生蛛网膜炎。在某些蛛网膜炎病例中，尤其是局灶性神经根鞘疤痕形成，原因尚不清楚。我们建议研究两种潜在因素在震源发展中的作用蛛网膜炎：神经根鞘的解剖扭曲和压迫神经根鞘局部暴露于核的某些成分牙髓。神经腐烂压迫将通过手术放置在适当的位置有小的骨碎片来伸展神经根部。接触到椎间盘材料的成分将是通过注射洗净的多道猴子髓核或将特定成分的椎间盘入硬膜外间隙围绕着神经根。这些动物将在12周时进行研究脊髓造影术以确定蛛网膜炎的程度。到那时，他们将成为处死动物，光镜检查腰椎蛛网膜区评分使用先前公布的蛛网膜炎标准。以下研究在以前的正常动物中，脊柱手术和造影剂的效果脊髓造影术对神经受压或暴露于神经的蛛网膜炎的诊断将对光盘材料进行检查。