MUSCLE RECEPTORS

肌肉受体

• 批准号: 3393690
• 负责人: CARLTON C HUNT
• 金额: $ 14.24万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1993-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393690
• 关键词: afferent nerve; axon; biological signal transduction; cats; central nervous system disorders; electron microscopy; evoked potentials; innervation; mechanical stress; mechanoreceptors; membrane permeability; membrane potentials; microscopy; muscle contraction; muscle tension; myelination; myofibrils; neural conduction; neural information processing; neural initiation; neuromuscular junction; neuromuscular transmission; stress; stretch receptors

This research aims to increase our understanding of sensory transduction in somatic mechanoreceptors. Such receptors subserve a wide variety of sensory systems which convert mechanical forces to neural signals which are transmitted to the central nervous system. Very little information is available on the fundamental steps of the transduction process. We propose a study on the primary ending of the isolated mammalian muscle spindle which is an especially favorable preparation for a direct approach on the problem because of: the ability to study it in isolation, the relatively large size of the myelinated branches and their terminals, the accessibility of structures in our isolated decapsulated preparation and the ability to visualize its structure microscopically. Using newly developed techniques of imaging and patch clamping, we will investigate: 1) the conductance changes which occur in the nerve terminals in response to mechanical stress and the characteristics of stretch-activated channels. 2) the spread of potentials produced by the conductance changes along the myelinated branches of the ending and the site of impulse initiation, and 3) a quantitative study of the structure of the primary ending both its myelinated branches and unmyelinated terminals, which will allow us to derive an electrical model of the ending. This is essential for the interpretation of an understanding of the overall transduction process in the ending. Knowledge of the basic mechanisms of transduction may be very important for the understanding of many disorders affecting sensory systems.

这项研究旨在增加我们对感官的理解 体细胞感受器的转导。 这样的受体予以吸引 转换机械力的多种感觉系统 传递给中枢神经的神经信号 系统。 关于基本的信息很少 转导过程的步骤。 我们提出了一项研究 孤立的哺乳动物肌肉纺锤的主要结局 对直接方法的特别准备 问题是因为：孤立地研究它的能力， 相对较大的骨髓分支及其 终端，我们孤立的结构的可访问性 拆除的准备和可视化其结构的能力 显微镜。 使用新开发的成像技术和 补丁夹，我们将调查：1）电导变化 响应机械应力而在神经终端发生的 以及拉伸激活通道的特征。 2） 电导沿线产生的电势的传播 结尾的髓鞘分支和冲动部位 启动和3）对结构的定量研究 主要结束其骨髓分支和不髓鞘 终端，这将使我们得出一个电气模型 结束。 这对于解释一个 了解结束中的整体转导过程。 了解转导基本机制可能非常 对于理解许多影响感官的疾病的重要 系统。