MOTOR UNIT ORGANIZATION

本研究旨在研究具有不同轴突传导的运动单位 速度相对于受神经支配的肌纤维的数量，其 横截面积和比张力（kg/cm 2）。数据应 指出这些变量中的哪一个负责精确和 轴突大小和力之间的重要关系， 抗疲劳的运动装置。单位为log 10最大强直张力 与轴突传导速度呈近似线性关系。单个马达 在腹侧分离猫浅蚓状肌的轴突 根，确定传导速度，标记单位的肌纤维 与C14 2-脱氧葡萄糖的混合物使用浅表蚓状动脉， 有2个头，可以在单个单元中进行成对单元之间的比较 动物，避免因动物间变异引起的数据分散。 将测量标记纤维的数量和直径;比张力 最大强直张力除以横截面 单位的纤维。停用后将进行类似的测量 （tenotomy）以确定哪些变量被改变。这与 废用导致肌肉深刻变化的临床病症。 还将对神经挤压后重新支配的肌肉进行研究， 确定纤维数量、面积、特定张力和空间 分布。这对神经系统的临床问题有明确的意义。 损伤和神经再生。

This research aims to study motor units having different axonal conduction velocities with respect to the number of muscle fibres innervated, their cross sectional areas and specific tensions (kg/cm2). The data should indicate which of these variables is responsible for the precise and important relation between axonal size and force developed in fatigue-resistant motor units. In such units log 10 maximal tetanic tension shows a nearly linear relation to axonal conduction velocity. Single motor axons to superficial lumbrical muscle of cat will be isolated in ventral root, conduction velocity determined and muscle fibres of a unit labeled with C14 2-deoxyglucose during activity. Using superficial lumbrical which has 2 heads, comparisons between pairs of units can be made in single animals, avoiding scatter in data introduced by interanimal variation. Numbers and diameters of labeled fibres will be measured; specific tension will be derived from maximal tetanic tension divided by cross sectional area of unit's fibres. Similar measurements will be made after disuse (tenotomy) to determine which variables are altered. This is relevant to clinical conditions in which disuse leads to profound changes in muscle. Studies will also be made in muscles reinnervated after nerve crush to determine fibre numbers, areas, specific tensions and spatial distributions. This has clear implications for clinical problems of nerve injury and reinnervation.