MUSCLE RECEPTORS

肌肉受体

• 批准号: 3393688
• 负责人: CARLTON C HUNT
• 金额: $ 14.43万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1979
• 资助国家: 美国
• 起止时间: 1979-01-01 至 1988-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3393688
• 关键词: afferent nerve; axon; cats; electron microscopy; evoked potentials; innervation; mechanoreceptors; membrane permeability; membrane potentials; microscopy; muscle contraction; muscle tension; myofibrils; neural information processing; neural initiation; neuromuscular junction; neuromuscular transmission; sarcomeres; stretch receptors

Mechanisms of sensory transduction and its modification by motor control will be studied in mammalian muscle spindles, both in situ and in isolated preparations. The membrane properties and contractile activation of intrafusal muscle fibers as well as their passive mechanical properties will be investigated using intracellular recording and stimulation and microscopic measurement of sarcomere length changes. The roles of the 2 types of nuclear bag fiber will be tested by activation of these fibers individually while observing the effect on the primary ending response to stretch. Possible stretch excitation in bag fibers will be studied. The conductance change in the sensory terminals in response to stretch will also be investigated as will the characteristics of impulse initiation in the primary ending.

感觉转导的机制及其运动调控 将在哺乳动物肌梭中进行研究，无论是在原位还是在分离的情况下 准备工作。膜特性和收缩活性的研究 梭内肌纤维及其被动力学性能 将通过细胞内记录和刺激进行研究 显微镜下测量肌节长度的变化。两人的角色 核袋纤维的类型将通过这些纤维的激活进行测试 分别观察其对初级结束反应的影响。 伸展一下。我们将研究袋状光纤中可能存在的拉伸激发。这个 感觉终末对伸展意志反应的电导变化 也将研究脉冲起爆的特性 主要的结局。