INNERVATION OF TISSUE
组织神经支配
基本信息
- 批准号:3399924
- 负责人:
- 金额:$ 11.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1983
- 资助国家:美国
- 起止时间:1983-07-01 至 1997-07-31
- 项目状态:已结题
- 来源:
- 关键词:autonomic nervous system axon biomarker dendrites electron microscopy histochemistry /cytochemistry immunocytochemistry innervation laboratory rat microtubule associated protein neural growth associated protein neural plasticity neurotransmitters nitric oxide penis erection postganglionic fiber preganglionic fiber protooncogene spinal cord injury splanchnic nerves synapses vasodilation vasodilators
项目摘要
There is sufficient reason to believe that the full consideration of
complications following injury of the nervous system should include
synaptic reorganization, in addition to the loss of specific neural
elements. Synaptic plasticity may occur at varied levels in the neural
pathways, which for visceral tissues such as the penis, include the
central nervous system, autonomic ganglia and peripheral target tissues.
Stimuli for reorganization in autonomic ganglia may be especially
vigorous, perhaps muting or at least influencing the course of change at
other levels. By documenting specific plastic changes in pelvic
autonomic pathways, the proposed studies are the first attempt to define
the milieu in the pelvic plexus subsequent to injury. Specifically, the
changing synaptology of penile parasympathetic neurons will be followed
after their partial or total disconnection from the spinal cord. These
studies model injury to the sacral portion of the spinal cord, including
that represented by direct trauma to the conus medullaris and cauda
equina or by conditions such as spina bifida. It is proposed to: (1)
use quantitative electron microscopy to describe the synaptology of
postganglionic penile neurons following interruption of preganglionic
nerves, (2) employ histochemistry and immunohistochemistry for
neurotransmitters/neuromodulators to determine whether penile neurons
reacquire a specific subset of presynaptic fibers, (3) analyze the
contribution of dendrites and axons to the emergent innervation of
decentralized penile neurons by staining for microtubular associated
protein (MAP-2) and growth associated protein (GAP-43), (4) analyze
changes in the neural circuitry in pelvic ganglia following nerve lesions
by using c-fos immunoreactivity as a metabolic marker, (5) to determine
whether hypogastric nerve-induced erection, apparent after nerve lesions,
is mediated by nitric oxide, (6) to determine whether the post-lesion,
plastic changes in the innervation of the corpus cavernosum also occurs
in the other erectile body of the penis, the corpus spongiosum. These
studies should unravel the degree to which the ordered arrangement of
pre- and postganglionic connections is altered by nerve injury. This
knowledge is central to understanding perturbations in control of
visceral organs and the application of strategies to improve function.
有充分的理由相信,充分考虑
神经系统损伤后的并发症应包括
突触重组,除了特定神经元的丧失之外
元素。 突触可塑性可能发生在神经元的不同水平上
对于阴茎等内脏组织来说,通路包括
中枢神经系统、自主神经节和周围靶组织。
对自主神经节重组的刺激可能尤其重要
充满活力,也许会减弱或至少影响变革的进程
其他级别。 通过记录骨盆的具体塑料变化
自主神经通路,拟议的研究是定义自主神经通路的首次尝试
受伤后骨盆丛的环境。 具体来说,
阴茎副交感神经元突触的变化将随之而来
在它们与脊髓部分或完全断开后。 这些
研究模拟脊髓骶骨部分的损伤,包括
以对髓圆锥和尾部的直接创伤为代表
马术或脊柱裂等疾病。 建议:(1)
使用定量电子显微镜来描述突触
节前神经元中断后的阴茎节后神经元
神经,(2)采用组织化学和免疫组织化学
神经递质/神经调节剂以确定阴茎神经元是否
重新获得突触前纤维的特定子集,(3)分析
树突和轴突对神经支配的贡献
通过微管相关染色分散阴茎神经元
蛋白(MAP-2)和生长相关蛋白(GAP-43),(4)分析
神经损伤后盆腔神经节神经回路的变化
通过使用 c-fos 免疫反应性作为代谢标志物,(5) 确定
是否是腹下神经引起的勃起,在神经损伤后明显,
由一氧化氮介导,(6) 以确定是否有病变后,
海绵体神经支配也会发生塑性变化
在阴茎的另一个勃起体中,即海绵体。 这些
研究应该揭示有序排列的程度
神经损伤会改变节前和节后连接。 这
知识对于理解控制扰动至关重要
内脏器官和改善功能的策略的应用。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM G DAIL其他文献
WILLIAM G DAIL的其他文献
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{{ truncateString('WILLIAM G DAIL', 18)}}的其他基金
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