INNERVATION OF PENILE ERECTILE TISSUE

阴茎勃起组织的神经支配

• 批准号: 3399926
• 负责人: WILLIAM G DAIL
• 金额: $ 7.88万
• 依托单位: UNIVERSITY OF NEW MEXICO
• 依托单位国家: 美国
• 财政年份: 1983
• 资助国家: 美国
• 起止时间: 1983-07-01 至 1988-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3399926
• 关键词: acetylcholine; electron microscopy; ganglions; histochemistry /cytochemistry; immunochemistry; innervation; mathematical model; microscopy; muscle contraction; muscle relaxants; neurofilament; neurophysiology; neurotransmitters; parasympathetic nervous system; penis; penis disorder; peripheral nervous system; smooth muscle; spinal cord injury; sympathetic nervous system; vasoactive intestinal peptide; vasodilation

The proposed research is an extension of our previous studies which have defined the neuroanatomical and neurohistochemical features of the innervation of penile erectile tissue. Using histochemical, immunohistochemical, dye tracing methods and lesion paradigms a map of the autonomic innervation of the penis has been generated. Evidence points to a coexistence of acetylcholine and vasoactive intestinal polypeptide in vasodilator nerves to the penis. The vasodilator pathway is quite separate anatomically from the vasoconstrictor pathway, located in the sympathetic chain. The existence of an alternate nerve pathway to the penis, via the hypogastric nerve, has been documented. It is believed that this newly described pathway participates in penile erection and may substitute for the major vasodilator pathway in instances of injury to the terminal spinal cord. Since there is considerable disagreement on the exact substances released by penile vasodilator nerves, the present studies will focus on the ability of acetylcholine and vasoactive intestinal polypeptide to effect relaxation of penile smooth muscle. More specifically, both substances will be tested for their ability to relax contracted smooth muscle strips of cavernous tissue in in vitro preparations and to affect electrically stimulated relaxations of penile smooth muscle. The discovery of a suprasacral pathway which travels via the hypogastric nerve to pelvic penile neurons offers a unique opportunity to study possible plastic changes in visceral innervation following spinal cord injury. We will investigate whether there are compensatory changes in penile innervation following nerve injury. One hypothesis is that after interruption of the pelvic nerve, an injury which models trauma to the terminal spinal cord, the ancillary penile vasodilator pathway in the hypogastric nerve will compensate for the loss of the main vasodilator pathway. Therefore, our pharmacological studies will be useful in understanding how putative neurotransmitter substances interact with penile smooth muscle. Study of the dual vasodilator pathways to erectile tissue may help clarify and estimate the effect on reproductive potency of an injury to the sacral spinal cord.

拟议的研究是我们以前研究的延伸， 定义了神经解剖学和神经组织化学特征， 阴茎勃起组织的神经支配。 利用组织化学， 免疫组化，染料示踪方法和病变范例 阴茎的自主神经支配已经产生。 证据都指向 乙酰胆碱和血管活性肠多肽的共存， 扩张血管的神经 血管扩张剂通路是相当独立的 解剖学上来自血管收缩通路，位于交感神经 链 存在一个替代的神经通路到阴茎，通过 腹下神经，已被记录。 据信，这一新 所描述的途径参与阴茎勃起，并且可以替代 在脊髓终末损伤的情况下， 线. 由于对释放的确切物质存在很大分歧， 通过阴茎血管扩张神经，目前的研究将集中在能力 乙酰胆碱和血管活性肠多肽，以实现松弛 阴茎平滑肌 更具体地说，这两种物质将被测试 因为它们能够放松收缩的海绵状血管平滑肌条， 组织在体外制剂和影响电刺激 阴茎平滑肌松弛。 骶上神经的发现 通过腹下神经到达骨盆阴茎神经元的通路 提供了一个独特的机会，研究可能的塑料变化， 脊髓损伤后的神经支配。 我们将调查是否 神经支配后阴茎神经支配发生代偿性变化， 损伤 一种假设是，在骨盆神经中断后， 损伤模型损伤终末脊髓，辅助 腹下神经中的阴茎血管舒张通路将补偿 主要血管扩张通路的丧失。 因此，我们的药理学 研究将有助于理解假定的神经递质 物质与阴茎平滑肌相互作用。 研究对偶 勃起组织的血管扩张通路可能有助于澄清和估计 骶骨脊髓损伤对生殖能力的影响。