INNERVATION OF PENILE ERECTILE TISSUE
阴茎勃起组织的神经支配
基本信息
- 批准号:3399925
- 负责人:
- 金额:$ 6.76万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1983
- 资助国家:美国
- 起止时间:1983-07-01 至 1986-07-31
- 项目状态:已结题
- 来源:
- 关键词:electron microscopy ganglions histochemistry /cytochemistry immunochemistry innervation microscopy neurofilament neurophysiology neurotransmitters parasympathetic nervous system penis penis disorder peripheral nervous system spinal cord injury sympathetic nervous system vasoactive intestinal peptide vasodilation
项目摘要
The vascular events of penile erection involve the coordinated integration
of the central and peripheral nervous systems. Penile erection is
jeopardized by spinal cord trauma, primary disease of the nervous system,
metabolic diseases such as diabetes, vascular lesions, and a host of
pharmacotherapeutic agents. Explanations of the neurophysiology of penile
erection in the normal and diseased state are hampered by an incomplete
data base. Fundamental questions remain on the actual neurotransmitter
substances responsible for vasodilation, the location of peripheral
ganglionic neurons which innervate the penis, the distribution of specific
nerve types within tissues of the penis and the possibility of two spinal
cord centers which mediate erection. Virtually nothing is known of the
changes which occur in the nerves of the penis following a lower motor
neuron injury. The primary aim of the present studies is to determine the
location of the various peripheral neurons which innervate the penis, the
type of neurotransmitter substance they contain, and to define their
distribution to the effector tissues within the penis of the rat. The
second aim is to characterize the changes which may occur in the
innervation of the penis following a lower motor neuron injury. This work
will be accomplished by histochemical and immunocytochemical methods at the
light and electron microscopic level. A focus of the proposed studies will
be the localization of vasoactive intestinal polypeptide (VIP), a proposed
mediator of penile erection, in neurons of the penis, and their
relationship to cholinergic type terminals. In effect, the innervation of
the penis will be studied as a model system in which to investigate the
possibility of dual transmitter substances within the same neuron. It is
anticipated that the data obtained from these studies will form a basis for
understanding the physiology of penile erection. The ultimate goal will be
to use this information to predict the changes which will occur in the
innervation of the penis of spinally-injured man. Such data would be
necessary to devise rational therapies in cases of lower motor neuron
injuries.
阴茎勃起的血管事件涉及协调整合
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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WILLIAM G DAIL其他文献
WILLIAM G DAIL的其他文献
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{{ truncateString('WILLIAM G DAIL', 18)}}的其他基金
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