INNERVATION OF PENILE ERECTILE TISSUE

阴茎勃起的血管事件涉及协调整合 中枢神经系统和外周神经系统。阴茎勃起是 受到脊髓损伤的威胁，这是神经系统的原发病， 代谢性疾病，如糖尿病、血管病变和许多 药物治疗剂。关于阴茎神经生理学的解释 在正常和患病状态下，勃起受到不完全勃起的阻碍 数据库。关于实际神经递质的基本问题仍然存在 负责血管扩张的物质，外周的位置 支配阴茎的神经节细胞的特殊分布 阴茎组织内的神经类型和两个脊柱的可能性 调节勃起的绳索中心。事实上，人们对这一事件一无所知 低位运动后阴茎神经发生的变化 神经元损伤。本研究的主要目的是确定 支配阴茎的各种外周神经元的位置， 它们所含的神经递质物质的类型，并定义它们的 分布于大鼠阴茎内的效应器组织。这个 第二个目标是描述可能发生在 低位运动神经元损伤后阴茎的神经支配。这部作品 将通过组织化学和免疫细胞化学方法在 光镜和电子显微镜水平。拟议研究的重点将是 血管活性肠多肽(VIP)的定位 阴茎勃起的中介物，在阴茎的神经元中，及其 与胆碱能终末的关系。实际上，大脑的神经支配 阴茎将被作为一个模型系统来研究 同一神经元内存在双重递质物质的可能性。它是 预期从这些研究中获得的数据将构成以下方面的基础 了解阴茎勃起的生理学。最终目标将是 使用此信息来预测将在 脊椎损伤男性阴茎的神经支配。这样的数据将是 有必要设计合理的治疗方法来治疗下运动神经元 受伤。

The vascular events of penile erection involve the coordinated integration of the central and peripheral nervous systems. Penile erection is jeopardized by spinal cord trauma, primary disease of the nervous system, metabolic diseases such as diabetes, vascular lesions, and a host of pharmacotherapeutic agents. Explanations of the neurophysiology of penile erection in the normal and diseased state are hampered by an incomplete data base. Fundamental questions remain on the actual neurotransmitter substances responsible for vasodilation, the location of peripheral ganglionic neurons which innervate the penis, the distribution of specific nerve types within tissues of the penis and the possibility of two spinal cord centers which mediate erection. Virtually nothing is known of the changes which occur in the nerves of the penis following a lower motor neuron injury. The primary aim of the present studies is to determine the location of the various peripheral neurons which innervate the penis, the type of neurotransmitter substance they contain, and to define their distribution to the effector tissues within the penis of the rat. The second aim is to characterize the changes which may occur in the innervation of the penis following a lower motor neuron injury. This work will be accomplished by histochemical and immunocytochemical methods at the light and electron microscopic level. A focus of the proposed studies will be the localization of vasoactive intestinal polypeptide (VIP), a proposed mediator of penile erection, in neurons of the penis, and their relationship to cholinergic type terminals. In effect, the innervation of the penis will be studied as a model system in which to investigate the possibility of dual transmitter substances within the same neuron. It is anticipated that the data obtained from these studies will form a basis for understanding the physiology of penile erection. The ultimate goal will be to use this information to predict the changes which will occur in the innervation of the penis of spinally-injured man. Such data would be necessary to devise rational therapies in cases of lower motor neuron injuries.