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INPUT OUTPUT RELATIONS IN VOLUNTARY MOVEMENT

随意运动的输入输出关系

基本信息

批准号：
3399207
负责人：
CLAUDE P GHEZ
金额：
$ 19.56万
依托单位：
NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC
依托单位国家：
美国
项目类别：
财政年份：
1982
资助国家：
美国
起止时间：
1982-07-01 至 1991-11-30
项目状态：
已结题

项目摘要

The proposed experiments investigate the neural mechanisms of rapid targeted responses of the limb and neck in the cat. Three groups of experiments are planned and are based on results obtained in the current period. First, we will ascertain the neural pathways that are responsible for transferring information from the target to the brain structures responsible for specifying trajectory parameters. This will be achieved by determining deficits in performance of a tracking task after reversible inactivation of several candidate pathways by injection of local anesthetics and other agents which block conduction or transmission of neural impulses. The primary question is to ascertain whether the processing of target information is mediated by the sensory cortical area or whether subcortical processing suffices. Each animal will serve as its own control and deficits produced by inactivation of different pathways will be compared in the same animal. Second, we will also define the changes in the preparation and execution of targeted responses following selective inactivation of two subregions of the motor cortex. [This part of the study, seeks to determine whether predictions deriving from our recent anatomical and physiological studies can be corroborated.] This experiment seeks principally to determine whether the prediction that the only rostral subregion of the arm area is concerned with response initiation. The third goal of the proposed work is to define the contributions of reticulospinal and other reticular neurons in the initiation and control of targeted neck and arm responses. Through single neuron recordings in the behaving animal we hope to ascertain the role of this neuronal system in the execution of the behaviors.

本实验研究了快速反应的神经机制。猫的肢体和颈部的靶向反应。三组计划进行实验，并根据目前获得的结果，期首先，我们要确定负责的神经通路将信息从目标转移到大脑结构负责指定轨迹参数。为实现这些目标将确定可逆后跟踪任务的表现缺陷通过注射局部药物灭活几种候选途径麻醉剂和其他药物，阻断传导或传输神经冲动主要问题是确定目标信息的处理由感觉皮质区介导或者皮层下处理是否足够。每只动物都将作为自身控制和不同途径失活产生的缺陷将在同一动物中进行比较。其次，我们还将定义有针对性的应对措施的准备和执行方面的变化运动皮层的两个亚区的选择性失活。 [This部分该研究的目的是确定是否预测来自我们的最近的解剖学和生理学研究可以证实。这实验主要是为了确定是否预测，只有臂区的吻侧亚区与反应有关入会仪式拟议工作的第三个目标是确定网状脊髓神经元和其他网状神经元的作用启动和控制有针对性的颈部和手臂反应。通过单神经元记录的行为动物，我们希望确定的作用，这个神经系统在执行行为的过程中。