3-D ANALYSIS OF AUDITORY BRAINSTEM RESPONSE COMPONENTS

听觉脑干反应成分的 3D 分析

• 批准号: 3405378
• 负责人: Don L. Jewett
• 金额: $ 17.74万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 1986
• 资助国家: 美国
• 起止时间: 1986-04-01 至 1989-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3405378
• 关键词: auditory pathways; auditory stimulus; axon; brain stem; diagnosis quality /standard; ear disorder diagnosis; electrical potential; fresh water environment; histology; stimulus /response

The goal of this research is to establish the surface potential patterns of elements of the Auditory Brainstem Response (ABR) in terms of the different axonal shapes and positions of neurons in the brainstem auditory system. The 3-Dimensional Lissajous Trajectory (3-CLT) is the resulting waveform when recordings from three orthogonally-placed electrodes are simulatneously plotted in three-dimensional voltage space. The 3-CLT of the ABR is known to produce planar curves whose shape and position are determined (at least in part) by the zonal portions of activated brainstem neurons. This research will examine the 3-CLT consequences of different axonal shapes and positions by placing a frog's nerve within a cat's skull filled with Ringer's solution, at the location of known brainstem axons. The success of this biological modelling will be measured by comparison with 3-CLT recordings from anesthetized cats, especially those in which only the VIIIth nerve is active. If successful, the research can be extended to study the likely contributions to human ABR recordings of specific neurons in the auditory brainstem system. Such an ability will provide more information as to how to interpret pathological changes in the ABR, a common clinical tool. Non-standard electrode placements to maximize the detection of abnormalities in specific neurons could be planned on the basis of this research. In addition, the effects of pre-amplifier filters, signal-to-noise ratio, and stimulus rate and intensity will be studied. Simpler methods for analyzing the 3-CLT will be evaluated using vector-time plots, and etection of straight line segments by analysis of the first derivative of the recorded waveforms.

本研究的目的是建立表面电位模式的 听性脑干反应（ABR）的不同成分 脑干听觉系统神经元的轴突形状和位置。 三维李萨如轨迹（3-CLT）是结果波形 当来自三个正交放置的电极的记录被 在三维电压空间中同时绘制。 3-CLT 已知ABR产生平面曲线，其形状和位置 由激活的脑干的带状部分决定（至少部分） 神经元 本研究将检查不同轴突的3-CLT后果 通过将青蛙的神经放入猫的头骨中， 用林格氏溶液在已知脑干轴突的位置。 的 这种生物建模的成功将通过与 3-来自麻醉猫的CLT记录，特别是那些只有 第八神经活跃。 如果成功，研究可以扩展到 研究特定神经元对人类ABR记录的可能贡献 在听觉脑干系统中。 这种能力将提供更多 关于如何解释ABR病理变化的信息， 临床常用工具 非标准电极放置以最大化 在特定的神经元异常的检测可以计划在 这项研究的基础。 此外，还讨论了前置放大器滤波器、信噪比、 并研究刺激速率和强度。 更简单的方法， 分析3-CLT将使用向量-时间图进行评估， 通过分析直线段的一阶导数， 记录波形。