TEMPORAL LOBE SINGLE UNIT ACTIVITY AND MEMORY

颞叶单个单位活动和记忆

• 批准号: 3412423
• 负责人: JAMES L RINGO
• 金额: $ 16.71万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-07-01 至 1993-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3412423
• 关键词: Macaca; brain commissure; brain electrical activity; interhemispheric transfer; memory; neural information processing; neurons; neuropsychology; single cell analysis; visual cortex

The board goal of this work is to understand and describe the neural mechanisms underlying visual memory. To do this the activity of single neurons in the cortex of the inferior temporal lobe will be monitored while a monkey is performing a visual memory task. A particular opportunity is provided by recording from the cells which form the anterior commissure. It is presently known - and important details are being actively pursued - that the anterior commissure can (by itself) transfer visual/mnemonic information between the hemispheres. Thus, the opportunity is available to sample the visual/mnemonic information as it is inescapably confined at the interhemispheric junction. The power in this arrangement is that at this stage, the entire message which allows recognition of a particular image by the other hemisphere is there. Further advantage will be taken of interhemispheric interaction to help separate storage and retrieval functions. The clinical relevance of this work is not immediate but may be no less profound for that. The contribution of this project is aimed directly at the cellular mechanisms of memory, and it would be rather surprising if a full understanding of those mechanisms did not have a major impact on the important - and increasing - health problems involving memory.

这项工作的董事会目标是理解和描述 视觉记忆的神经机制。要做到这一点， 颞下叶皮质单个神经元的活动 当一只猴子进行视觉检查时，脑叶将被监测 记忆任务。通过录制来提供特定的机会 从形成前连合的细胞中分离出来。它是 目前已知的重要细节正在积极进行中 追求--前连合可以(自行)转移 两个半球之间的视觉/助记信息。因此， 有机会品尝视觉/助记符 信息，因为它不可避免地被限制在半球之间 交叉口。这种安排的力量是，在这个阶段， 允许通过以下方式识别特定图像的整个消息 另一个半球在那里。我们将进一步利用 大脑半球之间的相互作用，有助于将存储和 检索功能。 这项工作的临床相关性不是立竿见影的，但可能是 这一点同样意义深远。这个项目的贡献是 直接针对记忆的细胞机制，它 如果能充分了解这些 机制没有对重要的--和 与日俱增的健康问题涉及到记忆。