STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY

刺激特异性适应和识别记忆

• 批准号: 2696011
• 负责人: JAMES L RINGO
• 金额: $ 25.66万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-07-01 至 2003-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2696011
• 关键词: Macaca nemestrina; brain interhemispheric activity; brain mapping; entorhinal cortex; experimental brain lesion; histology; memory; microelectrodes; psychological adaptation; split brain; stimulus /response; visual stimulus

DESCRIPTION: Recognition memory is a simple form of memory allowing well controlled experimental investigation. In the prototypical experiment, two separate presentations are made of a stimulus. In the first presentation the stimulus is novel and in the second it is familiar. In the last 25 years many laboratories have performed this type of experiment, seeking evidence of mechanisms underlying recognition by recording the spike trains from neurons in high level visual and association cortex of primates. One prominent candidate mechanism for recognition memory has been readily recorded under such circumstances, a decrement in response amplitude specific to previously presented images, called here a stimulus-specific adaptation (SSA). This SSA is robust; it has been recorded in many laboratories and is clearly evident in both single units and population averages from many areas (inferotemporal, perirhinal, entorhinal, V4, prefrontal cortex). Except under special behavioral circumstances, this is the only candidate mechanism which has been found for recognition memory in primates, and it is widely hypothesized to be the mediator of recognition memory. It was thus a surprise when the applicant was recently able to eliminate SSA from the neural responses of units recorded in inferotemporal cortex, without a concomitant elimination of behavioral recognition. The adaptation was eliminated by a using a unique, partial split-brain preparation in which two completely separate routes were used to bring information to the recorded units. Despite this result, SSA is still the leading, and currently really the only, candidate mechanism for recognition memory. The best way to reconcile this result with the hypothesis that SSA is the mechanism underlying recognition memory is to suggest that while the adaptation could be eliminated in inferotemporal cortex without eliminating behavioral recognition, this could not occur one or two stages further into higher level association cortex. To test this hypothesis, a series of experiments is proposed to determine whether SSA and behavioral recognition can be dissociated in entorhinal, perirhinal, and/or ventral prefrontal cortex.

产品说明： 识别记忆是一种简单的记忆形式， 实验研究 在原型实验中，两个独立的 演示文稿是由一个刺激。 在第一次介绍中， 刺激是新奇的，而第二个刺激是熟悉的。 在过去25年中 许多实验室都进行了这类实验， 通过记录大脑皮层的棘波序列， 灵长类动物的高级视觉和联想皮层神经元。 识别记忆的一个突出的候选机制已经很容易被 在这种情况下记录，响应幅度的减小 特定于先前呈现的图像，这里称为刺激特定 适应（SSA）。 这个SSA是强大的;它已被记录在许多 在实验室中，在单个单位和群体中都很明显 许多区域的平均值（颞下，鼻周，内鼻，V4， 前额叶皮层）。 除了在特殊的行为情况下，这是 唯一的候选机制，已被发现的识别记忆， 灵长类动物，它被广泛假设为识别的中介 记忆 因此，当申请人最近能够取消SSA时， 从颞下皮层记录的单位的神经反应， 而不伴随着行为识别的消除。 适应 是通过一种独特的部分裂脑制备方法来消除的， 两条完全不同的路线被用来把信息带到 记录单位 尽管如此，SSA仍然是领先的，目前真的是 识别记忆的候选机制。 和解的最佳方式 这一结果与假设，即SSA是机制的基础 再认记忆表明，虽然适应可能是 在颞下皮层消除，而不消除行为 承认，这不可能发生一个或两个阶段进一步进入更高的 水平联合皮层 为了验证这一假设， 提出，以确定是否SSA和行为识别可以 在内嗅、嗅周和/或腹侧前额叶皮层中分离。