STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY

说明： 识别记忆是一种简单的记忆形式，可以很好地控制 实验研究。在原型实验中，两个独立的 演讲都是由刺激计划组成的。在第一个演示中， 刺激是新奇的，在第二种情况下，它是熟悉的。在过去的25年里 许多实验室已经进行了这种类型的实验，以寻找证据 通过记录来自的棘波序列来识别潜在的机制 灵长类高级视觉皮质和联想皮质的神经元。 识别记忆的一种突出的候选机制很容易 在这种情况下记录的，反应幅度的减小 特定于先前呈现的图像，在此称为刺激特定 适应(SSA)。这个SSA是强大的；它已经被记录在许多 实验室，在单个单位和人口中都很明显 来自多个区域的平均值(颞下区、周围区、内嗅区、V4区、 前额叶皮质)。除非在特殊的行为情况下，否则这是 已发现的识别记忆的唯一候选机制 灵长类动物，它被广泛假设为认知的中介者 记忆。 因此，当申请人最近能够消除SSA时，这是一个惊喜 从记录在颞下皮质的单位的神经反应来看， 而不会伴随着行为识别的消除。改编 通过使用一种独特的部分分裂脑制剂来消除 两条完全不同的路线被用来将信息带到 记录的单位。 尽管有这样的结果，SSA仍然是领先的，而且目前确实是 只是，识别记忆的候选机制。和解的最好方式 这一结果是在假设SSA是潜在机制的情况下得出的 再认记忆是指，虽然适应可能是 在不消除行为的情况下，在颞下皮质中消除 认识到，这不可能发生在更高的一个或两个阶段 水平联结皮质。为了验证这一假设，我们进行了一系列实验 用来确定SSA和行为识别是否可以 在内嗅区、周围区和/或腹侧前额叶皮质中分离。

DESCRIPTION: Recognition memory is a simple form of memory allowing well controlled experimental investigation. In the prototypical experiment, two separate presentations are made of a stimulus. In the first presentation the stimulus is novel and in the second it is familiar. In the last 25 years many laboratories have performed this type of experiment, seeking evidence of mechanisms underlying recognition by recording the spike trains from neurons in high level visual and association cortex of primates. One prominent candidate mechanism for recognition memory has been readily recorded under such circumstances, a decrement in response amplitude specific to previously presented images, called here a stimulus-specific adaptation (SSA). This SSA is robust; it has been recorded in many laboratories and is clearly evident in both single units and population averages from many areas (inferotemporal, perirhinal, entorhinal, V4, prefrontal cortex). Except under special behavioral circumstances, this is the only candidate mechanism which has been found for recognition memory in primates, and it is widely hypothesized to be the mediator of recognition memory. It was thus a surprise when the applicant was recently able to eliminate SSA from the neural responses of units recorded in inferotemporal cortex, without a concomitant elimination of behavioral recognition. The adaptation was eliminated by a using a unique, partial split-brain preparation in which two completely separate routes were used to bring information to the recorded units. Despite this result, SSA is still the leading, and currently really the only, candidate mechanism for recognition memory. The best way to reconcile this result with the hypothesis that SSA is the mechanism underlying recognition memory is to suggest that while the adaptation could be eliminated in inferotemporal cortex without eliminating behavioral recognition, this could not occur one or two stages further into higher level association cortex. To test this hypothesis, a series of experiments is proposed to determine whether SSA and behavioral recognition can be dissociated in entorhinal, perirhinal, and/or ventral prefrontal cortex.