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REVERSIBLE DISRUPTION OF MEMORY

可逆的记忆破坏

基本信息

批准号：
6187720
负责人：
JAMES L RINGO
金额：
$ 23.22万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
1997
资助国家：
美国
起止时间：
1997-07-01 至 2001-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/6187720
关键词：
Macaca nemestrina behavior test behavioral /social science research tag brain electrical activity brain electronic stimulator electrodes electrostimulus frontal lobe /cortex implant memory performance sound stereotaxic techniques stimulus /response stimulus interval temporal lobe /cortex

项目摘要

Work in the previous support period led to a finding that electrical stimulation of the medial temporal lobe of monkeys during the delay period of a delayed matching-to-sample task was highly disruptive of performance if only a few images were repeatedly reused. The identical stimulation was only mildly disruptive if fresh images were used for each trial. In memory tasks with human subject, the use of repeated images leads to a strategy of active rehearsal during the delay period. In monkeys, the use of repeated images is a key to inducing the so- called delay activity. This is an elevated discharge rate in neurons usually lasting throughout the delay period, with different neurons selectively active for different stimuli. Thus, the activity across the population of neurons encodes a memory of that which is to-be- remembered. The delay activity appears like a neuronal version of continuous rehearsal, and is an excellent candidate for the neural embodiment of memory during the delay under these conditions. The fascination with this delay activity is that it may be our best model for the everyday human working memory which is the substrate for thought. The evidence that delay activity is the holder of the memory is, however, indirect. The purpose of the current proposal is to test that hypothesis directly. This will be done by using electrical stimulation which is known to disrupt that delay activity (see Preliminary Studies). If delay activity of neurons is the carrier of the memory then disruption of the delay activity should disrupt the behavioral memory. The contribution of this project is aimed directly at a prominent candidate neuronal mechanism of memory. Its clinical relevance is not immediate but could nonetheless be profound since a full understanding of the mnemonic circuitry should have a major impact on the important - and with the aging population - growing health problems involving memory.

上一个支持期间的工作发现，电气延迟期间对猴子内侧颞叶的刺激延迟匹配样本任务的时期具有高度破坏性如果仅重复使用少量图像，性能会受到影响。相同的如果使用新鲜图像，刺激只会产生轻微的破坏性每次审判。在人类受试者的记忆任务中，使用重复图像导致了在延迟期间积极排练的策略。在猴子中，使用重复图像是诱导如此的关键称为延迟活动。这是神经元放电率升高通常持续整个延迟期，具有不同的神经元对不同的刺激有选择性地活动。因此，整个活动神经元群编码对未来事物的记忆记得。延迟活动看起来像神经元版本持续排练，是神经网络的优秀候选者这些条件下的内存延迟的体现。这这种延迟活动的魅力在于它可能是我们最好的模型人类日常工作记忆是想法。延迟活动是记忆持有者的证据然而，是间接的。当前提案的目的是测试直接提出这个假设。这将通过使用电力来完成已知会破坏延迟活动的刺激（参见初步研究）。如果神经元的延迟活动是记忆然后延迟活动的中断应该扰乱行为记忆。该项目的贡献直接针对记忆的一个重要的候选神经元机制。其临床相关性不是直接的，但仍然可能是深远的，因为充分理解助记符电路应该会产生重大影响随着人口老龄化，健康日益重要涉及记忆力的问题。