STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY

刺激特异性适应和识别记忆

基本信息

  • 批准号:
    6182416
  • 负责人:
  • 金额:
    $ 26.98万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    1998
  • 资助国家:
    美国
  • 起止时间:
    1998-07-01 至 2003-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION: Recognition memory is a simple form of memory allowing well controlled experimental investigation. In the prototypical experiment, two separate presentations are made of a stimulus. In the first presentation the stimulus is novel and in the second it is familiar. In the last 25 years many laboratories have performed this type of experiment, seeking evidence of mechanisms underlying recognition by recording the spike trains from neurons in high level visual and association cortex of primates. One prominent candidate mechanism for recognition memory has been readily recorded under such circumstances, a decrement in response amplitude specific to previously presented images, called here a stimulus-specific adaptation (SSA). This SSA is robust; it has been recorded in many laboratories and is clearly evident in both single units and population averages from many areas (inferotemporal, perirhinal, entorhinal, V4, prefrontal cortex). Except under special behavioral circumstances, this is the only candidate mechanism which has been found for recognition memory in primates, and it is widely hypothesized to be the mediator of recognition memory. It was thus a surprise when the applicant was recently able to eliminate SSA from the neural responses of units recorded in inferotemporal cortex, without a concomitant elimination of behavioral recognition. The adaptation was eliminated by a using a unique, partial split-brain preparation in which two completely separate routes were used to bring information to the recorded units. Despite this result, SSA is still the leading, and currently really the only, candidate mechanism for recognition memory. The best way to reconcile this result with the hypothesis that SSA is the mechanism underlying recognition memory is to suggest that while the adaptation could be eliminated in inferotemporal cortex without eliminating behavioral recognition, this could not occur one or two stages further into higher level association cortex. To test this hypothesis, a series of experiments is proposed to determine whether SSA and behavioral recognition can be dissociated in entorhinal, perirhinal, and/or ventral prefrontal cortex.
描述: 识别记忆是一种简单的记忆形式,可以很好地控制 实验调查。 在原型实验中,两个独立的 演示是由刺激物组成的。 在第一个演示中 刺激是新奇的,而第二刺激是熟悉的。 在过去的25年里 许多实验室都进行过此类实验,寻求证据 通过记录来自的尖峰序列来识别潜在的机制 灵长类动物高级视觉和联合皮层的神经元。 一种重要的识别记忆候选机制已经很容易被发现 在这种情况下记录,响应幅度的减少 特定于先前呈现的图像,此处称为刺激特定 适应(SSA)。 该 SSA 非常稳健;它被记录在许多 实验室,并且在单个单位和总体中都清晰可见 来自许多区域的平均值(颞下、鼻周、内嗅、V4、 前额皮质)。 除特殊行为情况外,这是 已发现的识别记忆的唯一候选机制 灵长类动物,它被广泛假设为识别的中介 记忆。 因此,当申请人最近能够消除 SSA 时,我们感到惊讶 根据颞下皮质中记录的单元的神经反应, 而不同时消除行为识别。 适应 通过使用一种独特的部分裂脑制剂来消除,其中 使用两条完全独立的路线将信息传递给 记录的单位。 尽管如此,SSA 仍然处于领先地位,并且目前确实是领先的 仅是识别记忆的候选机制。 最好的和解方法 这个结果的假设是 SSA 是潜在的机制 识别记忆表明,虽然适应可能是 在颞下皮质中消除,但不消除行为 认识到,这不可能发生在进入更高阶段的一两个阶段 水平关联皮层。 为了验证这个假设,进行了一系列实验 建议确定 SSA 和行为识别是否可以 在内嗅、鼻周和/或腹侧前额皮质中解离。

项目成果

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JAMES L RINGO其他文献

JAMES L RINGO的其他文献

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{{ truncateString('JAMES L RINGO', 18)}}的其他基金

STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY
刺激特异性适应和识别记忆
  • 批准号:
    2889455
  • 财政年份:
    1998
  • 资助金额:
    $ 26.98万
  • 项目类别:
STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY
刺激特异性适应和识别记忆
  • 批准号:
    2696011
  • 财政年份:
    1998
  • 资助金额:
    $ 26.98万
  • 项目类别:
STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY
刺激特异性适应和识别记忆
  • 批准号:
    6387904
  • 财政年份:
    1998
  • 资助金额:
    $ 26.98万
  • 项目类别:
STIMULUS SPECIFIC ADAPTATION AND RECOGNITION MEMORY
刺激特异性适应和识别记忆
  • 批准号:
    6521048
  • 财政年份:
    1998
  • 资助金额:
    $ 26.98万
  • 项目类别:
REVERSIBLE DISRUPTION OF MEMORY
可逆的记忆破坏
  • 批准号:
    2891692
  • 财政年份:
    1997
  • 资助金额:
    $ 26.98万
  • 项目类别:
REVERSIBLE DISRUPTION OF MEMORY
可逆的记忆破坏
  • 批准号:
    2405530
  • 财政年份:
    1997
  • 资助金额:
    $ 26.98万
  • 项目类别:
REVERSIBLE DISRUPTION OF MEMORY
可逆的记忆破坏
  • 批准号:
    2714457
  • 财政年份:
    1997
  • 资助金额:
    $ 26.98万
  • 项目类别:
REVERSIBLE DISRUPTION OF MEMORY
可逆的记忆破坏
  • 批准号:
    6187720
  • 财政年份:
    1997
  • 资助金额:
    $ 26.98万
  • 项目类别:
TEMPORAL LOBE SINGLE UNIT ACTIVITY AND MEMORY
颞叶单个单位活动和记忆
  • 批准号:
    3412423
  • 财政年份:
    1988
  • 资助金额:
    $ 26.98万
  • 项目类别:
TEMPORAL LOBE SINGLE UNIT ACTIVITY AND MEMORY
颞叶单个单位活动和记忆
  • 批准号:
    3412422
  • 财政年份:
    1988
  • 资助金额:
    $ 26.98万
  • 项目类别:
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