Multi-electrode electromyography: developing electrical cross-sectional imaging of skeletal muscle.

多电极肌电图：开发骨骼肌的电横截面成像。

• 批准号: EP/K028421/1
• 负责人: Roger Whittaker
• 金额: $ 71.99万
• 依托单位: Newcastle University
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2013
• 资助国家: 英国
• 起止时间: 2013 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FK028421%2F1
• 关键词: Multi; electrode; electromyography; developing; electrical

Needle electromyography (EMG) is an essential diagnostic test in the investigation of patients with peripheral nerve and muscle disease. For conditions such as motor neuron disease, a relentlessly progressive degeneration of the motor system, it is the only diagnostic test available. However, current EMG technology has barely advanced in the past 50 years. EMG involves inserting a metal needle through the skin into a muscle, and recording the electrical activity produced by the muscle fibres. Diseases affecting the motor nerves or the muscle produce characteristic changes in this electrical activity. The signal is recorded from a single point at the needle tip, and herein lies the fundamental limitation of current technology. Since only a single recording surface is used, this 'single channel' recording consists of overlapping electrical signals from dozens of individual muscle fibres, and untangling these to work out how the muscle fibres are arranged within the muscle can be difficult. Furthermore, the volume of muscle sampled is tiny, meaning that in order to diagnose a widespread disease, such as motor neuron disease, the needle has to be repositioned several times within several muscles. This increases the pain for the patient and means that some studies can take over an hour to perform. Our proposal is to adapt and develop existing microfabrication techniques to produce a novel EMG electrode, of similar diameter to a conventional needle, which will record simultaneously from 64 points along the needle. This will allow the rapid and accurate localisation of each individual muscle fibre within the muscle without the need for needle movement, in effect producing an electrical cross-sectional image of the muscle. This will massively increase the accuracy of the test and significantly reduce the time taken. Our group consists of clinicians and basic scientists based within the Royal Victoria Infirmary, Newcastle and Newcastle University. We have already developed multi-electrodes for recording electrical activity from within the brain, using microfabrication facilities within Newcastle University. We will adapt these to record from human muscle, and will test these in human volunteers. We also have extensive experience in developing novel software to analyse the data from multi-channel recordings, and we will develop a suite of programs to display muscle structure and function in real-time. This will allow clinicians to view the results as they are collected allowing them to decide whether a diagnosis has been reached or if further muscles need to be studied. Our ultimate aim is to develop a prototype clinically applicable system which we will then develop in partnership with a commercial medical instrument company. There are approximately 100,000 EMGs performed each year in the UK. Even if our system reduces the time taken by ten minutes each, this will have a massive cost saving for the NHS, quite apart from the benefits to patients in terms of improved diagnosis and reduced discomfort. We believe that this technique is achievable, and will be as revolutionary for EMG as the development of magnetic resonance imaging has been for radiology.

针肌电图（EMG）是一种重要的诊断测试，在周围神经和肌肉疾病的患者的调查。对于运动神经元疾病（一种运动系统不断进行性退化的疾病）等疾病，这是唯一可用的诊断测试。然而，目前的EMG技术在过去50年中几乎没有进步。肌电图包括将金属针穿过皮肤插入肌肉，并记录肌肉纤维产生的电活动。影响运动神经或肌肉的疾病在这种电活动中产生特征性变化。该信号是从针尖处的单个点记录的，并且这是当前技术的基本限制。由于只使用一个记录表面，这种“单通道”记录由来自数十个单独肌肉纤维的重叠电信号组成，并且解开这些以确定肌肉纤维如何在肌肉内排列可能是困难的。此外，采样的肌肉体积很小，这意味着为了诊断广泛的疾病，如运动神经元疾病，针必须在几块肌肉内重新定位几次。这增加了患者的痛苦，并意味着一些研究可能需要一个多小时才能完成。我们的建议是适应和发展现有的微加工技术，以生产一种新的EMG电极，类似的直径，传统的针，这将同时记录从64点沿着针。这将允许快速和准确地定位肌肉内的每个单独的肌纤维，而不需要针移动，实际上产生肌肉的电横截面图像。这将大大提高测试的准确性，并显着减少所需的时间。 我们的团队由皇家维多利亚医院、纽卡斯尔和纽卡斯尔大学的临床医生和基础科学家组成。我们已经开发了多电极，用于记录大脑内部的电活动，使用纽卡斯尔大学的微加工设备。我们将调整这些记录从人类肌肉，并将测试这些在人类志愿者。我们在开发新软件以分析多通道记录的数据方面也有丰富的经验，我们将开发一套程序来实时显示肌肉结构和功能。这将使临床医生能够在收集结果时查看结果，从而决定是否已经达到诊断，或者是否需要进一步研究肌肉。 我们的最终目标是开发一个原型临床应用系统，然后我们将与商业医疗仪器公司合作开发。在英国，每年大约有100，000例EMG检查。即使我们的系统将每个人所需的时间减少10分钟，这将为NHS节省大量成本，除了在改善诊断和减少不适方面对患者的好处之外。我们相信这项技术是可以实现的，并且将像磁共振成像的发展对放射学一样对EMG产生革命性的影响。

项目成果

W:Ti Intraneural Flexible Electrode for Acute Peripheral Nerve Stimulation Studies

用于急性周围神经刺激研究的 W:Ti 神经内柔性电极

• DOI: 10.1109/icecs49266.2020.9294866
• 发表时间: 2020
• 作者: Silveira C

W:Ti Flexible Transversal Electrode Array for Peripheral Nerve Stimulation: A Feasibility Study.

用于周围神经刺激的 W:Ti 柔性横向电极阵列：可行性研究。

• DOI: 10.1109/tnsre.2020.3014812
• 发表时间: 2020
• 期刊: a publication of the IEEE Engineering in Medicine and Biology Society
• 作者: Silveira C

Reply.

回复。

• DOI: 10.1002/art.40923
• 发表时间: 2019
• 期刊: Arthritis & rheumatology (Hoboken, N.J.)
• 作者: Kim,AlfredHJ;Strand,Vibeke;Atkinson,JohnP
• 通讯作者: Atkinson,JohnP