NEWBORN SCREENING FOR C.F.

新生儿 CF 筛查

• 批准号: 3434671
• 负责人: KEITH B HAMMOND
• 金额: $ 0.6万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-09-30 至 1991-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434671
• 关键词: cystic fibrosis; mass screening; newborn human (0-6 weeks); travel

This proposed International Meeting on Newborn Screening for Cystic Fibrosis is designed to provide current information on neonatal screening for Cystic Fibrosis (CF) to physicians (pediatric pulmonologists, gastroenterologists, pathologists, geneticists), State Health Department laboratory personnel, nutritionists and clinical psychologists. Investigators from the United States and several other countries will be invited to present their clinical and laboratory experience in CF screening. Such a meeting is considered timely, since the recent discovery of the CF gene may provide a new technique for screening and diagnosis, and its potential for improving the neonatal screening process is under active investigation at several centers around the world. The gene discovery and its implications for neonatal screening will be a major focus of this meeting. The ethical issues surrounding newborn carrier detection will also be discussed. Another session will focus on quality control issues in newborn screening for CF, and experience with an international proficiency survey will be reviewed. The types of quality control programs that might need to be developed in the USA should mass screening be adopted will also be discussed. Clinical investigators will review early mechanisms of lung injury in CF, and current data regarding early pulmonary manifestations and interventions in screened infants. Early nutritional abnormalities, and their implications and response to early treatment will also be discussed. A session will be devoted to the psychosocial and ethical issues of false positive screening tests, and the impact of early diagnosis on the families of affected infants. This conference should be valuable to policy makers who wish to determine whether or not newborn screening for this disease should be widely implemented in the United States. The proceedings will be published as a supplement to "Pediatric Pulmonology".

本次拟议中的新生儿囊性癌筛查国际会议 纤维化的目的是提供目前的信息新生儿筛查 对于囊性纤维化（CF）， 胃肠病学家、病理学家、遗传学家），州卫生部 实验室人员、营养学家和临床心理学家。 来自美国和其他几个国家的调查人员将在 邀请他们介绍CF的临床和实验室经验 筛选这样的会议被认为是及时的，因为最近发现 CF基因的克隆为CF的筛选和诊断提供了新的技术手段， 它在改善新生儿筛查过程方面的潜力尚未发挥作用， 在世界各地的几个中心进行调查。基因的发现和 它对新生儿筛查的影响将是这一研究的主要焦点。 会议围绕新生儿携带者检测的伦理问题也将 可以讨论。另一次会议将集中讨论质量控制问题， 新生儿CF筛查，并具有国际熟练程度的经验 将对调查进行审查。质量控制程序的类型可能 如果大规模筛查被采用， 可以讨论。临床研究者将回顾肺损伤的早期机制， CF中的损伤，以及关于早期肺部表现和 对筛查婴儿的干预。早期营养异常，以及 并讨论其影响和早期治疗的反应。 一个会议将专门讨论虚假的社会心理和道德问题。 阳性筛查试验，以及早期诊断对家庭的影响 受影响的婴儿。这次会议应该对决策者有价值 他们希望确定新生儿筛查这种疾病 应该在美国广泛实施。过程将 作为《小儿肺病学》的增刊发表。