FASEB SUMMER RESEARCH CONFERENCE: CELL/MOLECULAR BIOLOGY

这是一个部分资金的申请，以支持在一个 FASEB夏季生物学研究会议系列 胃肠道（GI）。 这些会议已经举行， 一年两次的活动非常成功。 的科学重点 每一次会议都有所不同;然而，一个不变的目标是， 仍然需要将现有的调查人员与年轻的 科学家和受训人员讨论地理信息学前沿的主题 research. 拟议会议的另一个目标是提请注意 的GI研究人员的相关见解来自研究， 他们可能不会接触到的相关学科。 的 会议将在铜山的非正式环境中举行 科罗拉多的滑雪胜地，利用淡季的经济优势， 这使得年轻和成熟的科学家都有可能 以最低限度的财政援助参加。 令人愉快的设置也 促进参与者之间的互动， 在正式会议期间，将在社会活动中进行。 的 这次会议的需要，以及它的主题，胃肠道 第四章：发育和修复-细胞和分子方面达成一致 最后，与会者以压倒性多数投了赞成票， 上一次会议（胃肠道III）在铜 1989年7月的山。 焦点受到热烈欢迎， 令人兴奋，并针对现代研究的前沿， 领域 这是所有人都感兴趣的，要么是因为它关系到他们的利益， 自己目前正在进行的工作，或因为它是教育价值， 他们希望在未来做的研究。 一个额外的好处，实现在 上一次会议在下一次会议上应该更加明显， 参与的细胞和分子生物学家从他们的接触中获得 与GI科学家的赞赏和洞察力的整合， 决定一个整体更高层次行为的调节功能 器官. 因此，无论是临床上的， 胃肠病学和基础研究。 目标将在 部分，通过举行会议：（1）干细胞和发展（更新 （2）肠上皮细胞和区域特异性调节 上皮细胞基因表达;（3）上皮细胞分化模型; (4)极化上皮细胞功能的形成与维持 (5)粘液免疫中的内吞和转胞作用;（6）细胞外 胃肠细胞分化的调节;（7）细胞迁移 （8）神经嵴和胃肠道 发展;（9）肠道炎症/过敏反应和神经 功能 几次会议将补充讨论者，他们将 预先通知演讲者的演讲和谁将准备 开始讨论，并介绍其有争议的方面， 话题 青年调查员的海报摘要和非正式 在集体用餐、下午休息和社交活动中的谈话 晚上的会议后将有助于最大限度地提高互动之间 参与者

This is an application for partial funding to support the fourth in a series of FASEB summer research conferences on the biology of the gastrointestinal (GI) tract. These conferences have been held biannually have been remarkably successful. The scientific focus of each meeting has differed; however, a constant objective has been and remains to bring established investigators together with young scientists and trainees to confer on topics at the frontiers of GI research. Another goal of the proposed meeting is to draw the attention of GI investigators to relevant insights derived from research in related disciplines to which they might not otherwise be exposed. The meeting will be held in the informal surroundings of the Copper Mountain ski resort in Colorado, taking advantage of economical off-season rates, which make it possible for both young and established scientists to attend with a minimum of financial aid. The pleasant setting also facilitates interactions between participants, so that ideas raised during formal sessions will be pursued during social activities. The need for this conference, as well as its topic, Gastrointestinal Tract IV: Development and Repair-Cellular and Molecular Aspects were agreed upon by an overwhelmingly positive vote of the participants at the end of the previous conference (Gastrointestinal Tract III) at Copper Mountain in July, 1989. The focus was enthusiastically greeted as exciting and directed to the advancing front of modern research in the field. It was of interest to all, either because it related to their own current work in progress or because it was of educational value for research they wished to do in the future. An added benefit, realized in the previous conference that should be even more evident in the next, is that attending cellular and molecular biologists gain from their contact with GI scientists an appreciation and insight into the integration and regulatory functions that determine higher levels of behavior of a whole organ. Funamental advantages thus accrue both for clinical gastroenterology and basic research. Objectives will be achieved, in part, by holding sessions on: (1) Stem Cells and Development (Renewal of Epithelium); (2) Cell and Region-Specific Regulation of Intestinal Epithelial Gene Expression; (3) Models of Epithelial Differentiation; (4) Development and Maintenance of Polarized Epithelial Cell Function; (5) Endocytosis and Transcytosis in Mucosal Immunity; (6) Extracellular Modulation of Gastrointestinal Cell Differentiation; (7) Cell Migration and Repair of the Epithelium; (8) The Neural Crest and Gastrointestinal Development; (9) Intestinal Inflammation/Anaphylaxis and Neural Function. Several sessions will be supplemented discussants, who will be forewarned about the speakers presentations and who will be prepared to begin discussion and to introduce controversial aspects of their topics. Poster summaries by young investigators and informal conversations during group dining, afternoon recesses, and socialization after evening sessions will contribute to maximizing interactions among participants.