Development of the enteric nervous system: Cells & genes

描述（由申请人提供）： 在过去的10年中，有许多关于肠神经系统发育的研究发表在Science，Nature，Neuron，Nature Genetics，Gastroenterology，Journal of Neuroscience and Development等期刊上。这些研究包括广泛多样的方法，包括人类先天性巨结肠症的遗传学研究，斑马鱼遗传学，以及使用鸟类和各种突变和转基因小鼠和大鼠的细胞和分子生物学研究。许多研究的动机是希望了解一些肠神经系统发育障碍，包括先天性巨结肠症，慢传输型便秘和婴儿肥厚性幽门狭窄。该研究领域是动物模型理解人类疾病（先天性巨结肠症）的力量的一个很好的例子。最近的研究表明，干细胞可以从发育和成人肠神经系统中分离出来，并且在将这些肠神经干细胞用于治疗目的方面存在巨大的兴趣。重要的是，发育中的肠神经系统也为神经发育和细胞迁移提供了许多见解。至今还没有专门讨论肠神经系统发展的会议。我们会议的主要目标是第一次汇集对肠神经系统发展感兴趣的研究人员的多样性。我们的会议也将是感兴趣的研究人员感兴趣的成人运动的控制，因为在发育研究中发现的一些分子可能在成人功能的维持中发挥关键作用，并可能是恢复或修复肠道神经回路的策略的主要目标。主题包括干细胞，迁移途径，先天性巨结肠的遗传学，遗传筛选，肠道动力的发展，Sox 10，内皮素-3，Ret信号，途径之间的相互作用。受邀演讲者包括该领域的所有领先研究人员，包括Nicole Le Douarin教授。我们还预计，许多研究生和博士后研究员也将参加。

DESCRIPTION (provided by applicant): In the past 10 years, there have been many studies published on the development of the enteric nervous system in journals including Science, Nature, Neuron, Nature Genetics, Gastroenterology, Journal of Neuroscience and Development. These studies have included a broad diversity of approaches including genetic studies of humans with Hirschsprung's disease, zebrafish genetics, and cell and molecular biological studies using avians and a variety of mutant and transgenic mice and rats. Many of the studies were motivated by a desire to understand a number of developmental disorders of the enteric nervous system including Hirschsprung's disease, slow transit constipation and infantile hypertrophic pyloric stenosis. This research field is an excellent example of the power of animal models to understand a human disease (Hirschsprung's disease). Recent studies have shown that stem cells can be isolated from the developing and adult enteric nervous system, and there is enormous interest in the use of these enteric neural stem cells for therapeutic purposes. Importantly, the developing enteric nervous system has also provided many insights into neural development and cell migration in general. There has not yet been a conference devoted to the development of the enteric nervous system. The main goal of our meeting is to bring together, for the first time, the diversity of researchers interested in the development of the enteric nervous system. Our meeting will also be of interest to researchers interested in the control of adult motility as some of the molecules identified in developmental studies are likely to play key roles in the maintenance of function in adults, and are likely to be major targets in strategies to restore or repair enteric neural circuits. Topics to be covered include stem cells, migratory pathways, genetics of Hirschsprung's disease, genetic screens, development of gut motility, Sox10, endothelin-3, Ret signaling, interactions between pathways. The invited speakers include all of the leading researchers in the field, including Professor Nicole Le Douarin. We also anticipate that many post-graduate students and post-doctoral fellows will also attend.