PATHOBIOLOGY OF GI INFECTION AND INFLAMATION

哥伦比亚大学的一个多学科高级研究小组，对保护肠道免受微生物感染的机制有共同的兴趣，设计了一个胃肠道感染和炎症培训计划，并请求支持。1年招收2名博士预科生，2年招收3名博士预科生，3-5年招收4名博士预科生。从历史上看，在哥伦比亚大学，感染的基础研究集中在微生物学系。然而，发病机制的研究越来越多地涉及细胞生物学的研究，因为入侵生物有能力利用宿主细胞机制来实施其邪恶的生命周期。同样地，微生物学家现在也和以细胞生物学命名的部门成员一样关注细胞生物学。因此，让受训者广泛接触许多学科是既现实又重要的。细菌和病毒的发病机制提供了一个很好的多学科培训机会，我们现在建议充分利用这个机会。此外，最好的博士前申请者对疾病的机制感兴趣，并希望将其纳入博士前培训。因此，来自4个基础科学部门和3个临床科学部门的18名教师联合起来，共同开发了一个主题，跨部门的胃肠道感染和炎症博士预科培训项目。参与教授包括：Q. Al-Awqati（肠道上皮的分化和膜运输）；J. Bulinski（微管在细胞内运输中的作用）；M. Field（离子跨肠上皮膜运输）；M. Gershon（肠神经系统的发育与功能）；A. Gershon（疱疹病毒和艾滋病毒感染）；S. Goff（逆转录病毒感染和复制）；G. Gundersen（膜运输的微管控制）；R. Kessin（吞噬作用机制）；R. Liem（肠神经系统细胞骨架）；J. Luan （HIV-1复制及发病机制）；A. Mitchell（真菌感染，白色念珠菌）；L. Pon（肌动蛋白细胞骨架对膜运输和肠杆菌感染的控制）；A. Prince（细菌-宿主相互作用）；V. Racaniello（肠病毒致病）；H.舒曼（肠杆菌的发病机制）；S. Silverstein（膜运输和白细胞）；和H. Worman（炎症性肠，肝胆疾病和丙型肝炎）。这个项目的多学科性质与哥伦比亚大学研究生教育的发展是一致的。它还提供了多年来第一次对胃肠道疾病的研究和研究培训的机构关注。该计划的启动已经导致了新的研究生课程的发展，现有课程的扩展和新的合作的建立。

DESCRIPTION (adapted from the application) A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection, have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luan (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations.