PATHOBIOLOGY OF GI INFECTION AND INFLAMATION

胃肠道感染和炎症的病理学

• 批准号: 7015532
• 负责人: MICHAEL D GERSHON
• 金额: $ 4.13万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7015532
• 关键词: PATHOBIOLOGY; GI; INFECTION; INFLAMATION

JJ Principal Investigator/Program Director (Last, first, middle): ^ Gershnn, M.D. DESCRIPTION: State the applicatiorrsDroao^M-ferm objectives and specitic aims, maKing reference lo^BfieaTth relatedness ot the project. Describe concisely the research design and methods for achievinlHIse goals. Avoid summaries of past accomplishments ari^B use of the first person. This description is meant to A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection,have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luban (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and Hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations. serve as a succinct ana accurate description ot the proposed wornwhen separated from the application, it tne application is lunded, this description, as is, will Columbia University, College of Physicians and Surgeons 630 West 168th Street New York, NY 10032 PERFORMANCE SITE ========================================Section End===========================================

JJ主要研究者/项目负责人（最后，第一，中间）：^ Gershnn，医学博士说明：说明申请人的项目目的和具体目标，并说明与项目的相关性。简要描述研究设计和方法，以达到预期目标。避免使用第一人称来总结过去的成就。本说明是为了哥伦比亚的一个多学科高级研究人员小组，对保护肠道免受微生物感染的机制有着共同的兴趣，他们设计了一个胃肠道感染和炎症培训计划，并请求支持。申请的资金用于第一年的2名博士前研究员、第二年的3名博士前研究员和第三至第五年的4名博士前研究员。从历史上看，在哥伦比亚，感染的基础研究是集中在部门。微生物学然而，致病机制的研究越来越多地涉及细胞生物学的研究，因为入侵生物体能够利用宿主细胞机制来进行其邪恶的生命周期。同样，微生物学家现在也和以这个名字命名的部门的成员一样关心细胞生物学。因此，让学员广泛接触多种学科既现实又重要。细菌和病毒的发病机制提供了一个伟大的多学科培训的机会，我们现在建议充分利用。此外，最好的博士前申请人对疾病的机制感兴趣，并希望将其纳入博士前培训。因此，来自4个基础和3个临床科学部门的18名教师共同开发了一个主题，跨部门的GI感染和炎症博士前培训计划。参与教师包括：Q。Al-Awqati（肠上皮细胞的分化和膜运输）; J. Bulinski（细胞内运输中的微管功能）; M.场（离子转运穿过肠上皮膜）; M. Gershon（肠神经系统的发育和功能）; A. Gershon（疱疹病毒和HIV感染）; S. Goff（逆转录病毒感染和复制）; Gundersen（微管控制膜运输）; R. Kessin（吞噬作用机制）; Liem（肠神经系统的细胞骨架）; J. Luban（HIV-1复制和发病机理）; A. Mitchell（真菌感染，白色念珠菌）; Pon（肌动蛋白细胞骨架控制膜运输和肠细菌感染）; Prince（细菌-宿主相互作用）; V. Racaniello（肠道病毒发病机制）; H. Shuman（肠杆菌的发病机制）; Silverstein（膜转运和白细胞）;和H. Worman（炎症性肠病、肝胆疾病和丙型肝炎）。该计划的多学科性质与哥伦比亚大学研究生教育的发展是一致的。它还提供了，多年来第一次，在GI疾病的研究和研究培训的机构重点。该计划的开始已经导致了新的研究生课程的开发，现有课程的扩展和新的合作的建立。当与本申请分开时，作为对所提出的磨损的简洁和准确的描述，如果提交本申请，则该描述将由哥伦比亚大学内科医生和外科医生学院纽约西168街630号提供，NY 10032性能现场=

项目成果

Large-scale gene disruption using the UAU1 cassette.

• DOI: 10.1007/978-1-60327-151-6_17
• 发表时间: 2009
• 期刊: Methods in molecular biology (Clifton, N.J.)
• 作者: Nobile, Clarissa J.;Mitchell, Aaron P.
• 通讯作者: Mitchell, Aaron P.