PATHOBIOLOGY OF GI INFECTION AND INFLAMATION

描述(根据申请改编)哥伦比亚大学的一个由多学科的高级研究人员组成的小组，对保护肠道免受微生物感染的机制有共同的兴趣，他们设计了一项GI感染和炎症培训计划，并请求支持。1年级有2名博士前研究员，2年级有3名博士前研究员，3-5年级有4名博士前研究员。从历史上看，在哥伦比亚大学，关于感染的基础研究集中在部门。微生物学的研究。然而，发病机制的研究越来越多地涉及细胞生物学的研究，因为入侵生物能够利用宿主细胞机制来执行其邪恶的生命周期。类似地，微生物学家现在和以这个名字命名的系成员一样关心细胞生物学。因此，让受训人员广泛接触许多学科既现实又重要。细菌和病毒致病学提供了一个很好的多学科培训机会，我们现在建议充分利用这一机会。此外，最好的博士前申请者对疾病的机制感兴趣，并希望将其纳入博士前培训。因此，来自4个基础系和3个临床科学系的18名教员联合起来，开发了一个关于胃肠道感染和炎症的主题、跨部门的博士前培训计划。参与人员包括：Q.Al-Awqati(肠道上皮细胞分化和膜转运)；J.Bulinski(细胞内微管功能)；M.field(跨肠上皮膜离子转运)；M.Gershon(肠道神经系统的发育和功能)；A.Gershon(疱疹病毒和HIV感染)；S.Goff(逆转录病毒感染和复制)；G.Gundersen(微管控制膜转运)；R.Kessin(吞噬机制)；R.Liem(肠道神经系统的细胞骨架)；J.Luan(HIV-1复制和发病机制)；A.Mitchell(感染真菌，白色念珠菌)；L.Pon(肌动蛋白细胞骨架控制膜运输和肠道细菌感染)；A.Prince(细菌-宿主相互作用)；V.racaniello(肠道病毒致病机制)；H.SHuman(肠道细菌的发病机制)；S.Silverstein(膜运输和白细胞)；H.Worman(炎症性肠道、肝胆疾病和丙型肝炎)。该项目的多学科性质与哥伦比亚大学研究生教育的演变是一致的。多年来，它还首次将机构重点放在胃肠道疾病的研究和研究培训上。该方案的启动已经导致了新研究生课程的开发、现有课程的扩展和新的合作关系的建立。

DESCRIPTION (adapted from the application) A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection, have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luan (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations.