PATHOBIOLOGY OF GI INFECTION AND INFLAMATION

胃肠道感染和炎症的病理学

• 批准号: 6628379
• 负责人: MICHAEL D GERSHON
• 金额: $ 17.23万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6628379
• 关键词: PATHOBIOLOGY; GI; INFECTION; INFLAMATION

DESCRIPTION (adapted from the application) A multidisciplinary group of senior investigators at Columbia, with a common interest in the mechanisms that protect the bowel from microbial infection, have designed a GI Infection and Inflammation training program and request support. Funds are requested for 2 pre-doctoral fellows in the year 1, 3 pre-doctoral fellows in year 2 and 4 pre-doctoral fellows in years 3-5. Historically, at Columbia, basic research on infection was centered in the Dept. of Microbiology. Study of pathogenesis, however, has increasingly involved the study of cell biology, because of the ability of invading organisms to exploit host cell machinery to carry out their nefarious life cycles. Similarly, microbiologists are now just as concerned about cell biology as members of the department that bears that name. It is thus both realistic and important to expose trainees broadly to many disciplines. Bacterial and viral pathogenesis provides a great multidisciplinary training opportunity of which we now propose to take full advantage. In addition, the best pre-doctoral applicants are interested in the mechanisms of disease and want it included in their predoctoral training. Accordingly, 18 faculty from 4 basic and 3 clinical science departments have joined together to develop a thematic, interdepartmental pre-doctoral training program in GI infection and inflammation. Participating faculty include: Q. Al-Awqati (differentiation & membrane trafficking of gut epithelium); J. Bulinski (microtubule function in intracellular transport); M. Field (ion transport across intestinal epithelial membranes); M. Gershon (development & function of the enteric nervous system); A. Gershon (Herpes virus and HIV infection); S. Goff (retrovirus infection & replication); G. Gundersen (microtubule control of membrane trafficking); R. Kessin (mechanisms of phagocytosis); R. Liem (cytoskeleton of the enteric nervous system); J. Luan (HIV-1 replication & pathogenesis); A. Mitchell (infection by the fungus, Candida albicans); L. Pon (actin cytoskeletal control of membrane trafficking & enterobacterial infection); A. Prince (bacteria-host interactions); V. Racaniello (enterovirus pathogenesis); H. Shuman (pathogenesis of enterobacteria); S. Silverstein (membrane transport & leukocytes); and H. Worman (inflammatory bowel, and hepatobiliary diseases and hepatitis C). The multidisciplinary nature of this program is congruent with an evolution of graduate education at Columbia University. It also provides, for the first time in years, an institutional focus on research and research training in GI disease. The inception of this program has already led to the development of new graduate courses, expansion of existing courses and establishment of new collaborations.

描述（改编自申请）哥伦比亚大学的一个多学科高级研究人员小组对保护肠道免受微生物感染的机制有着共同的兴趣，设计了胃肠道感染和炎症培训计划并请求支持。为第一年的 2 名博士前研究员、第二年的 3 名博士前研究员和第三年至第五年的 4 名博士前研究员请求资金。从历史上看，在哥伦比亚大学，感染的基础研究主要集中在微生物学系。然而，由于入侵生物体能够利用宿主细胞机制来执行其邪恶的生命周期，因此发病机制的研究越来越多地涉及细胞生物学的研究。同样，微生物学家现在和同名部门的成员一样关注细胞生物学。因此，让学员广泛接触许多学科既现实又重要。细菌和病毒发病机制提供了一个很好的多学科培训机会，我们现在建议充分利用这一机会。此外，最好的博士前申请者对疾病机制感兴趣，并希望将其纳入他们的博士前培训中。因此，来自 4 个基础科学系和 3 个临床科学系的 18 名教师联合起来，制定了胃肠道感染和炎症主题、跨部门的博士前培训项目。参与的教师包括：Q. Al-Awqati（肠道上皮的分化和膜运输）； J. Bulinski（细胞内运输中的微管功能）； M. 场（跨肠上皮膜的离子传输）； M. Gershon（肠神经系统的发育和功能）； A. Gershon（疱疹病毒和艾滋病毒感染）； S. Goff（逆转录病毒感染和复制）； G. Gundersen（膜运输的微管控制）； R. Kessin（吞噬作用机制）； R. Liem（肠神经系统的细胞骨架）； J. Luan（HIV-1复制和发病机制）； A. Mitchell（真菌感染，白色念珠菌）； L. Pon（肌动蛋白细胞骨架控制膜运输和肠细菌感染）； A. Prince（细菌-宿主相互作用）； V. Racaniello（肠道病毒发病机制）； H. Shuman（肠细菌的发病机制）； S. Silverstein（膜运输和白细胞）；和 H. Worman（炎症性肠病、肝胆疾病和丙型肝炎）。该项目的多学科性质与哥伦比亚大学研究生教育的演变是一致的。它还多年来首次提供了一个专注于胃肠道疾病研究和研究培训的机构。该计划的启动已经导致了新的研究生课程的开发、现有课程的扩展以及新合作的建立。