Childhood Cognitive Antecedents of Adult Psychopathology: Follow-up of the Port Pirie Lead Cohort into Adulthood

成人精神病理学的童年认知前因：皮里港领先队列成年期的随访

• 批准号: nhmrc : 453563
• 负责人: A/Pr Peter Baghurst
• 金额: $ 39.16万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/childhood-cognitive-antecedents-cohort-adulthood/94546
• 关键词: Childhood; Cognitive; Antecedents; Adult; Psychopathology

The role of childhood factors in the development of adult psychiatric disorder is an important public health concern. Indvividuals identified before birth and followed across the life course offer the most powerful means of establishing predictors for particular types of psychiatric disorder. Not only do these studies enable researchers to more clearly determine the exact age of onset of disorder but they also give us insight into the background and hence possible risk factors that may have lead to the development of that disorder. Early identification of disorder can significantly reduce public health cost and reduce the burden on the community by enabling individuals to get help before their symptoms become too severe and unmanageable. Few long-term studies have investigated the combined role of pre-natal, developmental, parental characteristics, biological and childhood cognitive risk factors in the development of adult psychiatric dysfunction. Even fewer studies have examinined this interrelationship in a group of individuals who have been exposed to an environmental toxin such as lead. This study will follow-up 723 adults from the lead smelting city of Port Pirie who were originally recruited between 1979 and 1982. All adults were exposed to lead to some degree in childhood and have been followed over various time points over the course their lives. This project will be conducted 27 years since they were first involved, and will hence be one of the longest studies to be conducted in this field. The extensive information already collected on this group of individuals will enable us to create a very comprehensive picture of risk and protective factors for various types of adult disorder.

儿童期因素在成人精神障碍发展中的作用是一个重要的公共卫生问题。在出生前识别的个体，并在整个生命过程中进行跟踪，为建立特定类型精神障碍的预测因素提供了最有力的手段。这些研究不仅使研究人员能够更清楚地确定疾病发病的确切年龄，而且还使我们深入了解了可能导致疾病发展的背景和可能的风险因素。早期识别疾病可以显著降低公共卫生成本，减轻社区负担，使个人能够在症状变得过于严重和难以控制之前获得帮助。很少有长期研究调查了产前、发育、父母特征、生物学和儿童认知危险因素在成人精神功能障碍发展中的综合作用。在暴露于铅等环境毒素的人群中检验这种相互关系的研究就更少了。这项研究将追踪723名来自铅冶炼城市皮里港的成年人，他们最初是在1979年至1982年间招募的。所有成年人在童年时期都接触过不同程度的铅，并在他们一生中的不同时间点进行了跟踪调查。这个项目将进行27年，因为他们第一次参与，因此将是在这个领域进行的最长的研究之一。已经收集到的关于这群人的广泛信息将使我们能够非常全面地了解各种成人障碍的风险和保护因素。