Children of parents with mental illness: a population-based study

父母患有精神疾病的孩子：一项基于人群的研究

• 批准号: nhmrc : 458702
• 负责人: Prof Assen Jablensky
• 金额: $ 51.66万
• 依托单位: The University of Western Australia
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2007
• 资助国家: 澳大利亚
• 起止时间: 2007-01-01 至 2009-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/children-parents-mental-based-study/101128
• 关键词: Children; parents; mental; illness; population

Schizophrenia, bipolar disorder and major depression account for about 16% of the global burden of disease, according to estimates by the World Health Organization and the World Bank. These disorders tend to run a chronic or recurrent course, with devastating impact on sufferers and their families. We know today that part of their causes are genetic and may be transmitted to the next generation. However, another part of the causation is likely to be environmental, involving maternal pregnancy complications, as well as psychosocial adversity and stressful events impacting children who happen to carry a genetic susceptibility to such disorders. To disentangle and understand better such effects, our research is focusing on families where genetic risk to the offspring is present, due to a mother suffering from one of these disorders. By linking data available on population databases in WA, we aim to follow up the childhood development and young adult health outcomes of all children born to women with schizophrenia, bipolar disorder or depression. Few studies of this kind have been done worldwide, and we expect that the WA study will answer many unresolved questions, leading to preventative and treatment interventions that would reduce adverse outcomes and improve the quality of life of families at risk.

据世界卫生组织和世界银行估计，精神分裂症、双相情感障碍和重度抑郁症约占全球疾病负担的16%。这些疾病往往是慢性或复发性的，对患者及其家庭造成毁灭性的影响。我们今天知道，他们的部分原因是遗传的，可能会遗传给下一代。然而，另一部分原因可能是环境因素，涉及孕产妇妊娠并发症，以及影响儿童的心理社会逆境和压力事件，这些儿童碰巧携带对此类疾病的遗传易感性。为了更好地解开和理解这些影响，我们的研究集中在由于母亲患有这些疾病之一而对后代存在遗传风险的家庭。通过将西澳大利亚州人口数据库中的现有数据联系起来，我们的目标是跟踪精神分裂症、双相情感障碍或抑郁症妇女所生的所有儿童的儿童发育和青年健康结果。世界范围内很少进行此类研究，我们希望WA研究将回答许多尚未解决的问题，从而导致预防和治疗干预措施，减少不良后果并改善风险家庭的生活质量。