Chronic bacterial infection and the generation of T cell memory: implication for vaccination against tuberculosis

慢性细菌感染和 T 细胞记忆的产生：结核病疫苗接种的意义

• 批准号: nhmrc : 570768
• 负责人: A/Pr James Triccas
• 金额: $ 36.54万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/chronic-bacterial-infection-vaccination-tuberculosis/76964
• 关键词: Chronic; bacterial; infection; generation; cell

Two million people die from tuberculosis (TB) each year. The immune system is unable to eradicate the TB bacterium, and the type of immune response needed to protect against the disease is poorly understood. We will use animal models of TB infection and sophisticated immunological techniques to decipher how the TB bacterium interacts with the immune sytem and causes disease. We will also develop new TB vaccines that aim to boost the immune response in the lung, the main site of TB infection.

每年有200万人死于结核病。免疫系统无法根除结核病细菌，人们对预防这种疾病所需的免疫反应类型知之甚少。我们将使用结核病感染的动物模型和先进的免疫学技术来破译结核病细菌如何与免疫系统相互作用并导致疾病。我们还将开发新的结核病疫苗，旨在增强肺部的免疫反应，肺部是结核病感染的主要部位。