Regulation of pulmonary immune responses to subunit vaccines against tuberculosis

结核亚单位疫苗肺部免疫反应的调节

• 批准号: nhmrc : 512269
• 负责人: A/Pr James Triccas
• 金额: $ 33.95万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/regulation-pulmonary-immune-vaccines-tuberculosis/100264
• 关键词: Regulation; pulmonary; immune; responses; subunit

Tuberculosis (TB) remains an enormous health problem world-wide. Improving the effectiveness of anti-TB vaccines is essential for its control. The first approach to improving subunit TB vaccines will be to manipulate the cellular immune response to the vaccine by increasing the positive cytokine signals, or reducing inhibitory effects on the immune response. The second approach is to develop new subunit vaccines to deliver to the lung in order to increase the potency of the protective response.

结核病（TB）仍然是世界范围内的一个巨大的健康问题。提高抗结核疫苗的有效性对于控制结核病至关重要。改善亚单位TB疫苗的第一种方法是通过增加阳性细胞因子信号或减少对免疫应答的抑制作用来操纵对疫苗的细胞免疫应答。第二种方法是开发新的亚单位疫苗，将其输送到肺部，以提高保护性反应的效力。