Genes of Mycobacterium tuberculosis essential for Latent Tuberculosis Infection

潜伏性结核感染所必需的结核分枝杆菌基因

• 批准号: nhmrc : 1051246
• 负责人: A/Pr James Triccas
• 金额: $ 39.35万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/genes-mycobacterium-tuberculosis-tuberculosis-infection/112207
• 关键词: Genes; Mycobacterium; tuberculosis; essential; Latent

One third of the worlds population is latently infected with M. tuberculosis, the bacteria which causes TB. We have identified key genes in M. tuberculosis that enable the bacterium to shut-down and become latent. This project will investigate these genes, identify their role and yield vital information for a new paradigm of drug and vaccine development. Improved vaccines and drugs which can target and inhibit latency would be of enormous benefit to the global community.

世界上有三分之一的人口潜伏感染M.结核病，即导致结核病的细菌。我们已经确定了M中的关键基因。结核病，使细菌关闭，成为潜伏。该项目将研究这些基因，确定它们的作用，并为药物和疫苗开发的新范式提供重要信息。能够针对和抑制潜伏期的改进疫苗和药物将给全球社会带来巨大利益。