Impact of Influenza A infection on T cell-mediated immunity to pulmonary tuberculosis.

甲型流感感染对 T 细胞介导的肺结核免疫的影响。

• 批准号: nhmrc : 1011027
• 负责人: A/Pr James Triccas
• 金额: $ 32.54万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/impact-influenza-infection-pulmonary-tuberculosis/109544
• 关键词: Impact; Influenza; infection; cell; mediated

Tuberculosis is a leading cause of death worldwide and there is an urgent need to develop better anti-TB vaccines. Infection with respiratory viruses may reduce memory T cell responses to M. tuberculosis (Mtb). This project will investigate if Influenza A infection reduces memory anti-tuberculosis T cell responses in mice previously exposed to Mtb or BCG. We will then use influenza viruses engineered to carry parts of Mtb proteins to boost anti-Mtb T cell responses and the protective effect of BCG.

结核病是全世界的主要死因，迫切需要开发更好的抗结核疫苗。呼吸道病毒感染可降低记忆T细胞对M.结核病（Mtb）。本项目将研究甲型流感感染是否会降低先前暴露于结核分枝杆菌或卡介苗的小鼠的记忆性抗结核T细胞反应。然后，我们将使用经过工程改造的携带Mtb蛋白的流感病毒来增强抗Mtb T细胞反应和BCG的保护作用。