Visualisation of gamma-delta T cell responses in cutaneous inflammation

皮肤炎症中 γ-δ T 细胞反应的可视化

• 批准号: nhmrc : 632706
• 负责人: A/Pr James Triccas
• 金额: $ 38.07万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/visualisation-gamma-delta-cutaneous-inflammation/77994
• 关键词: Visualisation; gamma; delta; cell; responses

Mycobacterial infections remain a major burden of modern society. This proposal aims to define the role of an understudied immune cell subset, gamma-delta T cells, in the response against mycobacteria. We will use cutting-edge multi-photon imaging to track these cells in real-time directly within infected tissues. This will facilitate generating a new vista of anti-mycobacterial immune responses and may aid the development of improved vaccines.

分枝杆菌感染仍然是现代社会的主要负担。这项建议旨在确定一个未被研究的免疫细胞亚群--伽马-德尔塔T细胞--在对抗分枝杆菌的反应中所起的作用。我们将使用尖端的多光子成像技术，直接在感染组织内实时追踪这些细胞。这将有助于产生抗分枝杆菌免疫反应的新前景，并可能有助于改进疫苗的开发。