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MECHANISMS OF INDUCED TOLERANCE TO UV RADIATION IN SKIN

皮肤对紫外线辐射的诱导耐受机制

基本信息

批准号：
3456672
负责人：
RICHARD W GANGE
金额：
$ 9.04万
依托单位：
MASSACHUSETTS GENERAL HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
1985
资助国家：
美国
起止时间：
1985-09-20 至 1990-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/3456672
关键词：
DNA erythema human subject melanins melanocyte nonvisual photosensitivity photoprotection pigmentation radiation protection skin sunburn ultraviolet radiation

项目摘要

We will use quantitative techniques to measure the protective responses of normal skin to UVR as a function of heritable melanogenic capability and as a function of ultraviolet waveband. We will examine both melanin and non-melanin mechanisms. For the first time we will correlate structural and optical measurements in vitro with protection against erythema and against specific markers of epidermal and dermal damage. Responses will be compared in individuals of different genetic tanning capability and in response to different wavebands (UVA and UVB). UV-induced structural changes and alterations in optical transmissions by isolated epidermis and stratum corneum samples will be measured and correlated with the development of tolerance to insult by UVR. Tolerance will be assessed by measuring the degree of erythema, structural damage to dermal blood vessels, and damage to DNA in the epidermis resulting from further UV exposure. These studies will determine the relative importance of different protective mechanisms in subjects of different heritable pigmentation capabilities. We will determine whether Caucasians are heterogeneous with respect to their ability to develop tolerance to UVR by non-melanin mechanisms and, if so, whether differences correlate with or are dependent of tanning ability. The effects of UVA exposure upon melanocyte populations will be examined in different skin types, and the functional contribution of longwave induced changes to induced photoprotection will be examined.

我们将使用定量技术来测量正常皮肤到UVR作为可遗传的黑色素生成能力和AS的功能紫外线波段的函数。我们将同时检查黑色素和非黑色素机制。我们将第一次将结构性在体外进行光学测量，以防止红斑和针对表皮和皮肤损伤的特定标记物。回应将是比较了不同遗传制革能力的个体和对不同波段(UVA和UVB)的响应。紫外线诱导的结构离体表皮光透射率的改变和改变角质层样本将被测量并与对UVR侮辱的容忍度的发展。容忍度将通过以下方式评估测量红斑的程度，皮肤血液的结构性损害血管，以及进一步紫外线对表皮DNA的损伤曝光。这些研究将确定不同遗传性受试者的保护机制不同色素沉着能力。我们将确定高加索人是否他们通过以下方式发展对紫外线的耐受性的能力是不同的非黑色素的机制，如果是这样，差异是否与或取决于晒黑的能力。长波紫外线照射对人体健康的影响黑素细胞群将在不同的皮肤类型中进行检查，长波诱发改变对诱发改变的功能贡献将对光保护进行检查。