Optical Fabrication and Imaging Facility for three-dimensional sub-micron designer materials for bioengineering and photonics

用于生物工程和光子学的三维亚微米设计材料的光学制造和成像设备

• 批准号: EP/M000044/1
• 负责人: Stefan Maier
• 金额: $ 1.34万
• 依托单位: Imperial College London
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FM000044%2F1
• 关键词: Optical; Fabrication; Imaging; Facility; three

We propose a facility for 3D optical fabrication and imaging of nanomaterials, with applications in photonics and biomaterials. The facility will combine sub-micron fabrication of arbitrary shapes via a fast direct laserwriter and 3D microscopy of metal nanoparticles (or other light-scattering objects) within a material or biological tissue. Both the laserwriter and the microscope will be unique in the UK. The combination of 3D fabrication and imaging will generate applications in photonic materials, biomedical nanotechnology and tissue engineering, with spinout benefits across the full range of modern materials science.To date, the great majority of modern nanofabrication and imaging techniques are limited to two dimensions. Much is to be gained from extending capabilities into the third dimension. In photonics for example, the full vectorial character of light could be exploited, enabling unprecedented control over the propagation and storage of light with three-dimensional nanostructured materials, metamaterials. Here, designs for new types of filters, energy concentrators, and light sources exist on the drawing board, but have thus far not been realized due to absence of reliable and rapid fabrication, and quality assessment using 3D imaging.In the biological and biomaterials sciences, 3D images from confocal fluorescence microscopy have revolutionized our knowledge. However this approach cannot be applied to imaging non-fluorescent objects such as metal nanoparticles. The interactions of nanoparticles with biological tissue are becoming increasingly important from an environmental health perspective as nanoparticles find increasing use in consumer products. There is also the exciting prospect of using nanoparticles for therapeutic and diagnostic applications in clinical applications. For both these purposes, 3D imaging of nanoparticle cell interactions is required. Combining this approach with 3D fabrication of engineered scaffolds that combine with cells to form model tissues will generate improved in vitro assays for nanoparticle toxicology and the testing of nanotherapeutics, leading to improvements in human health and reducing the requirements for animal experiments.

我们提出了一种用于纳米材料 3D 光学制造和成像的设施，可应用于光子学和生物材料。该设施将通过快速直接激光写入器和材料或生物组织内金属纳米粒子（或其他光散射物体）的 3D 显微镜结合任意形状的亚微米制造。激光书写器和显微镜在英国都是独一无二的。 3D 制造和成像的结合将在光子材料、生物医学纳米技术和组织工程中产生应用，并在整个现代材料科学领域带来好处。迄今为止，绝大多数现代纳米制造和成像技术仅限于二维。将能力扩展到第三维度可以获得很多好处。例如，在光子学中，可以利用光的全矢量特性，从而利用三维纳米结构材料（超材料）对光的传播和存储进行前所未有的控制。在这里，新型滤波器、能量集中器和光源的设计已经在绘图板上，但由于缺乏可靠、快速的制造以及使用 3D 成像的质量评估，迄今为止尚未实现。在生物和生物材料科学中，共焦荧光显微镜的 3D 图像彻底改变了我们的知识。然而，这种方法不能应用于对非荧光物体（例如金属纳米粒子）进行成像。随着纳米粒子在消费产品中的使用越来越多，从环境健康的角度来看，纳米粒子与生物组织的相互作用变得越来越重要。在临床应用中使用纳米粒子进行治疗和诊断应用也具有令人兴奋的前景。为了这两个目的，需要对纳米颗粒细胞相互作用进行 3D 成像。将此方法与与细胞结合形成模型组织的工程支架的 3D 制造相结合，将产生改进的纳米粒子毒理学体外测定和纳米治疗药物测试，从而改善人类健康并减少对动物实验的要求。

项目成果

Fine-tuning of the optical properties of hollow-core light cages using dielectric nanofilms

• DOI: 10.1364/ol.45.000196
• 发表时间: 2020-01-01
• 期刊: OPTICS LETTERS
• 影响因子: 3.6
• 作者: Jang, Bumjoon;Gargiulo, Julian;Schmidt, Markus A.
• 通讯作者: Schmidt, Markus A.

Bianisotropy and Magnetism in Plasmonic Gratings

• DOI: 10.1021/acsphotonics.6b00206
• 发表时间: 2016-04
• 期刊: ACS Photonics
• 影响因子: 7
• 作者: M. Kraft;A. Braun;Yu Luo;S. Maier;J. Pendry

Versatile Direct Laser Writing Lithography Technique for Surface Enhanced Infrared Spectroscopy Sensors

• DOI: 10.1021/acssensors.6b00469
• 发表时间: 2016-09-01
• 期刊: ACS SENSORS
• 影响因子: 8.9
• 作者: Braun, Avi;Maier, Stefan Alexander
• 通讯作者: Maier, Stefan Alexander

Epithelial-stromal cell interactions and extracellular matrix mechanics drive the formation of airway-mimetic tubular morphology in lung organoids.

• DOI: 10.1016/j.isci.2021.103061
• 发表时间: 2021-09-24
• 期刊: iScience
• 影响因子: 5.8
• 作者: Güney TG;Herranz AM;Mumby S;Dunlop IE;Adcock IM
• 通讯作者: Adcock IM

Hollow Core Light Cage: Trapping Light Behind Bars

• DOI: 10.1021/acsphotonics.8b01428
• 发表时间: 2019-03-01
• 期刊: ACS PHOTONICS
• 影响因子: 7
• 作者: Jain, Chhavi;Braun, Avi;Schmidt, Markus A.
• 通讯作者: Schmidt, Markus A.