STATISTICAL METHODS FOR NON STANDARD DATA

这项赠款的目的是发展有用的统计方法 流行病学队列和病例对照研究， 和传染病。 重点将放在发展 统计方法（1）病例对照研究， 数据;（2）二元性状的遗传研究;（3） 关于死亡原因和/或死亡日期的部分信息，以及（4）病例- 流行病例对照研究。 上述四种不同类型的研究有一个共同点， 一般来说，以下两个假设中至少有一个是 被侵犯了 它们是（i）假设观测数据为 （二）疾病状态，特别是 发生的原因和日期，被认为是明确的， 鉴定 在这项补助金中，对于四项研究中的每一项，我们将（A） 指出现有统计数据的位置和程度 方法崩溃，（B）开发适合于 研究和（C）将方法应用于数据集， 工作的动机。

The objective of this grant is to develop statistical methods useful for epidemiologic cohort and case-control studies of both chronic and infectious diseases. The focus will be on the development of statistical methods for (1) case-control studies with dependent data; (2) genetic studies with binary traits; (3) cohort studies with partial information on causes and/or dates of death and (4) case- control studies with prevalent cases. The above four different types of studies share one thing in common, namely, at least one of the following two assumptions is violated. They are (i) the observed data are assumed to be independent of each other and (ii) the disease status, especially the cause and the date of occurrence, are assumed to be clearly identified. In this grant, for each one of four studies, we will (A) point out the place and the extent to which the existing statistical method breaks down, (b) develop new methods appropriate for the study and (C) apply the methods to the data set for which this work was motivated from.