Non-Communicable Diseases
非传染性疾病
基本信息
- 批准号:MC_UU_00033/3
- 负责人:
- 金额:$ 956.67万
- 依托单位:
- 依托单位国家:英国
- 项目类别:Intramural
- 财政年份:2023
- 资助国家:英国
- 起止时间:2023 至 无数据
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Non-communicable diseases (NCDs) pose a threat to sub-Saharan Africa (SSA), but there is little research to address this challenge. We have shown that NCD manifest differently in SSA. For example, mental illness is often seen with chronic infections (eg HIV). Similarly, type 2 diabetes occurs in lean individuals Africa, unlike in the West where it associates with obesity. Solutions from elsewhere may therefore not be necessarily effective in SSA. The unique NCD presentations are likely shaped by local factors, such as genetic susceptibility and other exposures, including infections and malnutrition. We aim to do rigorous research to uncover the fundamental underlying mechanisms, and to find best ways to prevent and treat these disorders in Africa. We will carefully characterise diabetes to see if it is caused either by lack of insulin (eg because the pancreas is small from previous malnutrition or infection) or because the insulin produced is not working well. We will test if drugs used to treat diabetes in the obese work in thin Africans. Building on our studies that have strongly linked HIV and depression, particularly in young people, we will design and test psychological intervention(s), delivered by lay health workers, to manage depression in young people living with HIV. As combination of infection and NCDs can cause huge disability, we will study how to improve the quality of life of people with disabilities, including through better access to healthcare.
非传染性疾病(NCD)对撒哈拉以南非洲(SSA)构成威胁,但几乎没有研究来应对这一挑战。我们已经证明,NCD在SSA中表现不同。例如,精神疾病经常与慢性感染(如艾滋病毒)一起出现。同样,2型糖尿病发生在非洲的瘦个体中,不像西方那样与肥胖有关。因此,其他地方的解决方案在撒南非洲不一定有效。独特的非传染性疾病表现可能受当地因素的影响,如遗传易感性和其他暴露,包括感染和营养不良。我们的目标是进行严格的研究,以揭示基本的潜在机制,并找到预防和治疗非洲这些疾病的最佳方法。我们将仔细检查糖尿病,看看它是由于缺乏胰岛素(例如,由于先前的营养不良或感染而导致胰腺变小)还是因为产生的胰岛素不起作用。我们将测试用于治疗肥胖的糖尿病的药物是否对瘦瘦的非洲人有效。我们的研究将艾滋病毒和抑郁症密切联系在一起,特别是在年轻人中,我们将设计和测试由非专业卫生工作者提供的心理干预措施,以管理艾滋病毒感染者的抑郁症。由于感染和非传染性疾病的结合可能导致巨大的残疾,我们将研究如何提高残疾人的生活质量,包括通过更好地获得医疗保健。
项目成果
期刊论文数量(10)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
"After all, we are all sick": multi-stakeholder understanding of stigma associated with integrated management of HIV, diabetes and hypertension at selected government clinics in Uganda.
- DOI:10.1186/s12913-022-08959-3
- 发表时间:2023-01-09
- 期刊:
- 影响因子:2.8
- 作者:
- 通讯作者:
PrEP uptake and persistence amongst HIV-negative women who exchange sex for money or commodities in Kampala, Uganda: A qualitative inquiry assessing the influence of pregnancy.
- DOI:10.1371/journal.pgph.0000434
- 发表时间:2023
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Factors associated with diagnostic and pre-treatment intervals among breast cancer patients attending care at the Uganda Cancer Institute: A cross-sectional study.
- DOI:10.1002/cam4.6618
- 发表时间:2023-10
- 期刊:
- 影响因子:4
- 作者:
- 通讯作者:
Pulmonary inflammation promoted by type-2 dendritic cells is a feature of human and murine schistosomiasis.
- DOI:10.1038/s41467-023-37502-z
- 发表时间:2023-04-03
- 期刊:
- 影响因子:16.6
- 作者:Houlder, E. L.;Costain, A. H.;Nambuya, I.;Brown, S. L.;Koopman, J. P. R.;Langenberg, M. C. C.;Janse, J. J.;Hoogerwerf, M. A.;Ridley, A. J. L.;Forde-Thomas, J. E.;Colombo, S. A. P.;Winkel, B. M. F.;Galdon, A. A.;Hoffmann, K. F.;Cook, P. C.;Roestenberg, M.;Mpairwe, H.;MacDonald, A. S.
- 通讯作者:MacDonald, A. S.
Statistical analysis plan and protocol updates for Gestational diabetes in Uganda and India: Design and Evaluation of Educational Films for Improving Screening and Self-management (GUIDES) trial.
- DOI:10.1186/s13063-023-07508-5
- 发表时间:2023-08-12
- 期刊:
- 影响因子:2.5
- 作者:
- 通讯作者:
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Moffat Nyirenda其他文献
Kangaroo mother care among hospitalised neonates: evaluation of the validity of duration measurement methods compared to observation linked to the OMWaNA trial in Uganda
- DOI:
10.1186/s12887-025-05629-1 - 发表时间:
2025-04-09 - 期刊:
- 影响因子:2.000
- 作者:
Victor S. Tumukunde;Isaac Sekitoleko;Charles Opondo;Moffat Nyirenda;Cally J. Tann;Joy E. Lawn;Melissa M. Medvedev - 通讯作者:
Melissa M. Medvedev
Good correlation between the Afinion AS100 analyser and the ABX Pentra 400 analyser for the measurement of glycosylated haemoglobin and lipid levels in older adults in Durban, South Africa.
Afinion AS100 分析仪和 ABX Pentra 400 分析仪在测量南非德班老年人的糖化血红蛋白和血脂水平时具有良好的相关性。
- DOI:
10.7196/samj.2017.v108i1.12548 - 发表时间:
2017 - 期刊:
- 影响因子:0
- 作者:
N. Abbai;Moffat Nyirenda;T. Reddy;Gita Ramjee - 通讯作者:
Gita Ramjee
Factors associated with non-adherence to clinic visits among patients with severe mental illness enrolled in the SMILE study in Uganda
- DOI:
10.1186/s12888-025-07121-7 - 发表时间:
2025-07-29 - 期刊:
- 影响因子:3.600
- 作者:
Richard Stephen Mpango;Wilber Ssembajjwe;Godfrey Zari Rukundo;Philip Amanyire;Carol Birungi;Allan Kalungi;Rwamahe Rutakumwa;Jonah Ibanda;Christine Tusiime;Kenneth D. Gadow;Vikram Patel;Moffat Nyirenda;Eugene Kinyanda - 通讯作者:
Eugene Kinyanda
Mentoring upcoming researchers for non-communicable diseases’ research and practice in Malawi
- DOI:
10.1186/s13063-020-05006-6 - 发表时间:
2021-01-19 - 期刊:
- 影响因子:2.000
- 作者:
Adamson S. Muula;Mina C. Hosseinipour;Martha Makwero;Johnstone Kumwenda;Prosper Lutala;Mary Mbeba;Sarah Rylance;Collins Mitambo;Moffat Nyirenda - 通讯作者:
Moffat Nyirenda
W10. THE UGANDA GENOME RESOURCE PROVIDES OPPORTUNITY FOR PSYCHIATRIC GENETIC RESEARCH IN AFRICA
W10. 乌干达基因组资源为非洲的精神病遗传学研究提供了机会
- DOI:
10.1016/j.euroneuro.2024.08.219 - 发表时间:
2024-10-01 - 期刊:
- 影响因子:6.700
- 作者:
Allan Kalungi;Eugene Kinyanda;Wilber Ssembajjwe;Joseph Mugisha;Moffat Nyirenda;Segun Fatumo - 通讯作者:
Segun Fatumo
Moffat Nyirenda的其他文献
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{{ truncateString('Moffat Nyirenda', 18)}}的其他基金
Glucocorticoids and foetal programming of adult hyperglycaemia: dissecting the fundamental molecular mechanisms
糖皮质激素和成人高血糖的胎儿编程:剖析基本分子机制
- 批准号:
G0501934/1 - 财政年份:2006
- 资助金额:
$ 956.67万 - 项目类别:
Fellowship
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