LUPUS COHORT-THROMBOTIC EVENTS & CORONARY ARTERY DISEASE

狼疮队列血栓事件

• 批准号: 3473641
• 负责人: MICHELLE A PETRI
• 金额: $ 11.69万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1991
• 资助国家: 美国
• 起止时间: 1991-09-30 至 1996-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3473641
• 关键词: blood coagulation tests; coronary disorder; disease /disorder proneness /risk; drug adverse effect; family genetics; female; gender difference; human age group; human subject; hyperlipidemia; hypertension; immunogenetics; lifestyle; longitudinal human study; male; medical complication; obesity; oral contraceptives; prednisone; socioeconomics; statistics /biometry; systemic lupus erythematosus; thrombosis; tobacco abuse; urinalysis; vasculitis

The Johns Hopkins Lupus Cohort is a longitudinal study, begun by Dr. Petri in 1987, of the incidence and pathogenesis of thrombotic events (TE) and coronary artery disease (CAD) in 225 patients with systemic lupus erythematosus (SLE) (60.2% black, 90.5% female, mean age 36.5 years). In SLE, both TE and CAD are a major cause of morbidity. The usual natural history of TE and CAD is telescoped, so that patients can present with these outcomes in their third and fourth decades. In our cohort study to date, 44 patients, have had past and 10 patients have had prospectively-followed thrombotic events. Thirteen patients (6.6%) have had coronary artery disease. We have prospectively followed our lupus cohort routinely every three months and have amassed a four-year database specifically designed to identify and to follow over time the most important risk factors for TE and CAD. Risk factors to be addressed in the study include: 1) the hypercoagulable state secondary to antiphospholipid antibodies (the lupus anticoagulant and anticardiolipin antibody); 2) premature atherosclerosis, accelerated by prednisone and hypertension; 3) underlying vascular damage from lupus vasculopathy and vasculitis; 4) co-morbid factors, including obesity, smoking, hyperlipidemia, hypertension, sedentary life style, and family history of CAD, and 5) other factors, including sex, age, race, immunogenetics, compliance with medication, and socioeconomic status. The Hopkins Cohort Study is uniquely able to focus on these issues, both because of its population, which reflects a broad racial, educational, and socioeconomic background, and because the four years of data accumulated to date show promising preliminary results. The five years of the proposed study will allow us to address further the incidence of TE and CAD, the importance of identified risk factors both singly and in combination, and to begin to address the issue of intervention to modify and reduce risk factors.

约翰霍普金斯狼疮队列是一项纵向研究，由佩特里博士开始 1987年，血栓事件（TE）的发生率和发病机制， 225例系统性狼疮患者的冠状动脉病变 红斑狼疮（SLE）（60.2%黑人，90.5%女性，平均年龄36.5岁）。 在 SLE、TE和CAD都是发病的主要原因。 通常的自然 TE和CAD的病史被压缩，因此患者可以表现出 这些成果在他们的第三和第四个十年。 在我们的队列研究中， 截至目前，44名患者，有过去和10名患者， 前瞻性随访血栓形成事件。 13名患者（6.6%） 患有冠心病 我们前瞻性地追踪了狼疮 定期每三个月进行一次队列研究，并积累了一个为期四年的数据库 专门设计来识别和跟踪最 TE和CAD的重要风险因素。 《公约》中应处理的风险因素 研究内容包括：1）抗磷脂继发高凝状态 抗体（狼疮抗凝剂和抗心磷脂抗体）; 2） 过早的动脉粥样硬化，由泼尼松和高血压加速; 3） 狼疮性血管病变和血管炎引起的潜在血管损伤; 4） 共病因素，包括肥胖，吸烟，高脂血症， 高血压、久坐生活方式和CAD家族史，以及5）其他 因素，包括性别，年龄，种族，免疫遗传学，依从性 药物和社会经济地位 霍普金斯队列研究是独一无二的 能够关注这些问题，既因为其人口， 反映了广泛的种族，教育和社会经济背景， 因为迄今为止积累的四年数据显示， 初步结果。 拟议研究的五年时间将使我们能够 进一步解决TE和CAD的发病率， 风险因素的单独和组合，并开始，以解决 采取干预措施以改变和减少危险因素问题。