HIGHLY SENSITIVE FIBER OPTIC SENSOR FOR CANCER DIAGNOSIS

基于荧光的光动力疗法已经证明了它在 识别异常细胞，评估预后，监测疾病。 但目前的光动力仪器太昂贵、太复杂，而且 缺乏早期肿瘤诊断所需的敏感性。面临的主要挑战 这项技术的关键是建立一种光纤系统，该系统可以 有效地将信号与背景隔离，准确地解析 荧光图谱，并对数据进行适当处理，以增加信号与信号的比率 噪声比。 为了响应对这项技术的需求，物理光学公司 (POC)提出了一种用于早期癌症的紧凑型多功能光纤系统 诊断。该系统使用POC的新型全息滤光片、波长 分路复用器(WDM)和光信号处理。由此产生的 探测器将非常紧凑，非常坚固，几乎不需要 维修。POC的光纤系统将很容易在 临床情况。建议的方法允许检测荧光- 组织中标志物浓度低至1.3 ng/ml。这是两份订单 比现有系统好很多。

Fluorescence-based photodynamic therapy has proved its potential for identifying abnormal cells, assessing prognosis, and monitoring disease. But the present photodynamic instruments are too costly, too complex, and lack sensitivity required for early tumor diagnosis. The major challenge of this technology is to build an optical fiber system which can efficiently isolate the signal from the background, accurately resolve the fluorescence profile, and properly process the data to increase signal-to- noise ratio. In response to the need for this technology, Physical Optics Corporation (POC) proposes a compact versatile fiber-optic system for early cancer diagnosis. This system uses POC's novel holographic filters, wavelength division multiplexers (WDM), and optical signal processing. The resulting detector will be extremely compact and highly rugged, requiring little maintenance. POC's fiber optic system will be easy to deploy under clinical conditions. The proposed method allows detection of fluorescence- marker concentrations as low as 1.3 ng/ml in tissues. This is two orders of magnitude better than the existing systems.